# CRISPR’s First Commercial Gene Therapy

By [fake](https://paragraph.com/@fake) · 2025-05-06

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The FDA approved **Casgevy**, the first CRISPR treatment for **sickle cell disease**, at **$2.2 million per patient**.

**How it works:**

*   **Edits bone marrow stem cells** to produce healthy hemoglobin
    
*   **One-time procedure** vs lifelong blood transfusions
    

**Controversies:**

*   **"Designer baby" ethical concerns**
    
*   **Insurance coverage battles**
    
*   **Global access inequality** (90% of sickle cell patients are in Africa)
    

This milestone opens doors for **CRISPR treatments targeting 6,000+ genetic disorders**.

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*Originally published on [fake](https://paragraph.com/@fake/crisprs-first-commercial-gene-therapy)*