# Pseudophenmetrazine

By [porquilho](https://paragraph.com/@porquilho) · 2022-03-01

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Pseudophenmetrazine is a psychostimulant compound of the morpholine class.[wikipedia\*\*](https://en.wikipedia.org/wiki/Pseudophenmetrazine)

### [Biological activity](https://hyperleap.com/topic/Biological_activity)

**bioactivebiologically activebioactivity**

In addition, along with phenmetrazine, it is believed to be one of the active metabolites of phendimetrazine, which itself is inactive and behaves merely as a prodrug.

### [Potency (pharmacology)](https://hyperleap.com/topic/Potency_\(pharmacology\))

**potentpotencypotencies**

Relative to phenmetrazine, pseudophenmetrazine is of fairly low potency, acting as a modest releasing agent of norepinephrine (EC 50 = 514 nM), while its -enantiomer is a weak releaser of dopamine (EC 50 = 1,457 nM) whereas its -enantiomer is a weak reuptake inhibitor of dopamine (K i = 2,691 nM); together as a racemic mixture with the two enantiomers combined, pseudophenmetrazine behaves overall more as a dopamine reuptake inhibitor (K i = 2,630 nM), possibly due to the -enantiomer blocking the uptake of the -enantiomer into dopaminergic neurons and thus preventing it from inducing dopamine release.

Hyperleap image

### [EC50](https://hyperleap.com/topic/EC50)

**EC 50 EC 50pEC 50**

Relative to phenmetrazine, pseudophenmetrazine is of fairly low potency, acting as a modest releasing agent of norepinephrine (EC 50 = 514 nM), while its -enantiomer is a weak releaser of dopamine (EC 50 = 1,457 nM) whereas its -enantiomer is a weak reuptake inhibitor of dopamine (K i = 2,691 nM); together as a racemic mixture with the two enantiomers combined, pseudophenmetrazine behaves overall more as a dopamine reuptake inhibitor (K i = 2,630 nM), possibly due to the -enantiomer blocking the uptake of the -enantiomer into dopaminergic neurons and thus preventing it from inducing dopamine release.

Hyperleap image

### [Reuptake inhibitor](https://hyperleap.com/topic/Reuptake_inhibitor)

**inhibitinhibitorinhibiting**

Relative to phenmetrazine, pseudophenmetrazine is of fairly low potency, acting as a modest releasing agent of norepinephrine (EC 50 = 514 nM), while its -enantiomer is a weak releaser of dopamine (EC 50 = 1,457 nM) whereas its -enantiomer is a weak reuptake inhibitor of dopamine (K i = 2,691 nM); together as a racemic mixture with the two enantiomers combined, pseudophenmetrazine behaves overall more as a dopamine reuptake inhibitor (K i = 2,630 nM), possibly due to the -enantiomer blocking the uptake of the -enantiomer into dopaminergic neurons and thus preventing it from inducing dopamine release.

Hyperleap image

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*Originally published on [porquilho](https://paragraph.com/@porquilho/pseudophenmetrazine)*