# Pseudophenmetrazine

**Published by:** [porquilho](https://paragraph.com/@porquilho/)
**Published on:** 2022-03-01
**URL:** https://paragraph.com/@porquilho/pseudophenmetrazine

## Content

Pseudophenmetrazine is a psychostimulant compound of the morpholine class.wikipedia** Biological activity bioactivebiologically activebioactivity In addition, along with phenmetrazine, it is believed to be one of the active metabolites of phendimetrazine, which itself is inactive and behaves merely as a prodrug. Potency (pharmacology) potentpotencypotencies Relative to phenmetrazine, pseudophenmetrazine is of fairly low potency, acting as a modest releasing agent of norepinephrine (EC 50 = 514 nM), while its -enantiomer is a weak releaser of dopamine (EC 50 = 1,457 nM) whereas its -enantiomer is a weak reuptake inhibitor of dopamine (K i = 2,691 nM); together as a racemic mixture with the two enantiomers combined, pseudophenmetrazine behaves overall more as a dopamine reuptake inhibitor (K i = 2,630 nM), possibly due to the -enantiomer blocking the uptake of the -enantiomer into dopaminergic neurons and thus preventing it from inducing dopamine release. Hyperleap image EC50 EC 50 EC 50pEC 50 Relative to phenmetrazine, pseudophenmetrazine is of fairly low potency, acting as a modest releasing agent of norepinephrine (EC 50 = 514 nM), while its -enantiomer is a weak releaser of dopamine (EC 50 = 1,457 nM) whereas its -enantiomer is a weak reuptake inhibitor of dopamine (K i = 2,691 nM); together as a racemic mixture with the two enantiomers combined, pseudophenmetrazine behaves overall more as a dopamine reuptake inhibitor (K i = 2,630 nM), possibly due to the -enantiomer blocking the uptake of the -enantiomer into dopaminergic neurons and thus preventing it from inducing dopamine release. Hyperleap image Reuptake inhibitor inhibitinhibitorinhibiting Relative to phenmetrazine, pseudophenmetrazine is of fairly low potency, acting as a modest releasing agent of norepinephrine (EC 50 = 514 nM), while its -enantiomer is a weak releaser of dopamine (EC 50 = 1,457 nM) whereas its -enantiomer is a weak reuptake inhibitor of dopamine (K i = 2,691 nM); together as a racemic mixture with the two enantiomers combined, pseudophenmetrazine behaves overall more as a dopamine reuptake inhibitor (K i = 2,630 nM), possibly due to the -enantiomer blocking the uptake of the -enantiomer into dopaminergic neurons and thus preventing it from inducing dopamine release. Hyperleap image

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