# Recently

**Published by:** [Superme002](https://paragraph.com/@superme002/)
**Published on:** 2021-10-28
**URL:** https://paragraph.com/@superme002/recently

## Content

Recently, an additional rare amino acid pyrrolysine (Pyl), was identified, which expanded the canonical genetic code to 22 amino acids . Pyl is inserted in response to UAG codon in several methanogenic archaea . Although the mechanism of Pyl biosynthesis and incorporation into protein is not fully understood, the presence of a tRNApyl gene (pylT) with the CUA anticodon and of class II aminoacyl-tRNA synthetase gene (pylS) argued for cotranslational incorporation of Pyl . In Desulfitobacterium hafniense, a single bacterium, in which a Pyl-containing protein was found, PylS consists of two proteins: PylSn and PylSc .

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