Overnight flights MU5165 were opened at 2345 a.m. The news jumped from article 1 was the announcement by WHO that the new crown no longer constituted a sudden public health incident of international concern (PHEIC).

From the well-known Beijing Capital Airport 2 station, the baggage hall is not in anybody’s minds, there is no numeracy or health code, and there does not seem to be any incident between the booths. The normal feeling is particularly good.

There is always new news in our news for more than three years. The Office’s outbreak map tells today the number of patients with heat, the number of new corons tested positive, and the number of viruses monitored by urban groundwater. Both the general population and health workers, or government officials, seem to fear a return to normal days and fear that the economic recovery that has just been active will be interrupted.

On the occasion of this five-year labour festival, the country’s population travels, and the flow data from and out of Shanghai cities are higher than those from 2019. We are concerned that the proportion of patients with emergency hospital care has increased slightly, but still far below the proportion of patients with hot visits during the influenza pandemic. The level of the virus in urban sewage, although slightly recovered, remains extremely low. Monitoring the new coronary sub-type in China has also been gradually and internationally converging, with XB B being the main focus, and with no stress on medical care.

The virus will also exist and the pandemic has passed. As far as the epidemic is concerned, the global warming has already taken place.

It has never happened, and everything has happened. All that goes through will allow us better to face the future. Let us go hand in hand to speed up our engagement in normal working life, be it difficult or easy to live, and we will see the future we look forward to if we are not going back.

On the evening of 26 April in Beijing, the 12th Bureau of the International Escard World champion in the capital of Kazakhstan, Astana, was struck in 2023, with a sharp reversal of the chess, with a total score of 6 to 6.

The slow chess of the competition remain the last two, tomorrow, 13th Bureau, followed by a day of war, on 28 April, and on the other hand, the attribution of the world chess title will be decided through the chesgase if the two sides are not at all.

The Dones of this Bureau, whose first two rounds appear to be coming to the opening of the London system, was then gradually gaining ground under the opening of London and eventually defeating the Niepo. It is clear that the chess are well-placed. Nippo is out of preparation and starts thinking on the response.

The latter chess have dealt with some of the problems, but the white chess have failed to seize the opportunity, and the two sides have maintained their positions, which have been won because of the lag behind the treachers, the rush to follow suit, the readiness of the white chess to attack at the throne-wing force, but the timing of the attacks has not reached their own insidivities.

The 19th round of retreats was the first problem of the trespasser, the opportunity to start a major offensive, the collapse of white chess and the worrisome situation.

By the twenty-seventh round, white chess were close to the negative, when a dramatic curtain was created, two chess were broken down and the minds of the chess accelerated, the chess were left out of the crisis and returned to the balance.

The mindset of the Neepo appears to be significantly affected, and in a time-consuming situation, the 34th round of black chess has been marked by a fatal failure, with a steady flow of the gift package from the rival.

The 38th round, the introduction of a transversal transpool and a major reversal of the dominator.

Now let’s “go through” the 120 second long time, and make the centennial history of Beijing Youth Movement “on the screen” through ingenious transition, ups and downs of music and color gradient of ink painting! Scan the code and watch! Text / our reporter Liu Jing

Photo production / Sha Nan Title calligraphy / Zheng Xinmei

Core tips

On December 17, 2020, the 15th UNESCO Intergovernmental Committee for the protection of intangible cultural heritage voted to include the “ship to the king” project jointly declared by China and Malaysia in the list of representative works of human intangible cultural heritage.

This is the first time that China has jointly declared a successful human intangible cultural heritage project with countries along the 21st century Maritime Silk Road.

“Send the king’s boat” is a ceremony created by the ancestors along the coast of Southern Fujian in the Ming Dynasty to comfort and sacrifice the shipwrecked victims. Minnan people call the victims of the shipwreck “good brothers”, and the local protective god of “patrolling and hunting on behalf of heaven” is “Lord”, “sending the king ship”, so it is also commonly known as “doing good deeds”. This custom is held by the temple or ancestral temple of the relevant community at the beginning of the northeast monsoon. It is generally held every three to four years, including welcoming the king, making a king’s boat, erecting a lamp pole, Pudu, sending the king’s boat (stepping on the street parade and burning the King’s boat).

With the sea trade and migration of people in Southern Fujian, the custom of sending King ships spread to Taiwan and the inhabited areas of overseas Chinese and ethnic Chinese in Southeast Asia from the 17th to the 20th century, which is an important legacy of the marine history and culture of Southern Fujian.

On the first anniversary of being selected into the list of representative works of human intangible cultural heritage, what kind of living inheritance has the activity of “sending the king’s boat” in Southern Fujian obtained in the context of local culture? This issue of “attention” presents you——

Zhang

“Ship” is bigger, and there are more ceremonies

Fujian Daily reporter Xiao Zhenping Yu Li correspondent Lin Jie Zheng Wendian

On the 19th, Baoquan palace in Shikeng community of Zhangzhou Development Zone held a lively activity of “sending the king’s boat”. Thousands of believers gathered in Baoquan palace to witness the triennial folk festival. Since the “King ship” was included in the list of representative works of human intangible cultural heritage a year ago, the “King ship” activity of representative communities in Zhangzhou has regained its luster.

The “King ship” with strange appearance is not just a model. It is completely modeled on Fu ship. The architecture on the ship restores the Xieshan roof in ancient China, and the ship body is painted with painted patterns representing good luck and peace. A “King ship” integrates a number of traditional skills of Southern Fujian.

“The ‘King ship’ in Shikeng community is now built of high-grade fir, which is solid and elegant. The statues and figures on the ship are made with color binding technology, which is lifelike.” Chen Yuanhui, head of Baoquan palace folk custom Learning Center, said that this year’s “King ship” is 8.9 meters long and 2.6 meters wide, “the largest ship since previous activities”.

Among the many temples, Jinfa palace, located in the Jiulong River Basin, is unique. It is the only “Water Temple” in the world, and its process of “sending the king ship” is completed on the water. It is reported that this is highly consistent with the lifestyle inherited by the local dans from generation to generation. Zheng Xiushan, President of the Council of the Jinfa palace, said that the third day of March of the lunar calendar is the birthday of the Jade Emperor. The “please king” invites the “Lord of the open sea” to “live” in the Jinfa palace for half a year to assist the gods enshrined in the temple and ensure the safety of the people. On September 13 of the lunar calendar, a ceremony of “sending the king” will be held.

In November this year, the activity of “sending the king’s boat” held in Jinfa palace added a celebration of successfully being listed as a “world-class intangible cultural heritage”. Yang Hui, a Zhangzhou cultural scholar who has been paying attention to the study of the dans’ customs in Jinfa palace, said that in previous years, the “King ship” turned auspicious on the river beach. This year, there was an additional “King ship” river patrol ceremony.

Experts believe that “sending the king ship” has become an important cultural carrier to connect the community people, promote the harmonious development of the community, and enrich the dialogue and cooperation between Fujian and Taiwan and even between China and Malaysia. It is a positive cultural phenomenon to promote righteousness and standardize behavior, which has been endowed with new era value.

At present, Baoquan palace folk custom Transmission Center encourages more villagers, especially young people, to learn the production skills and related knowledge of “King ship”, so as to ensure the living inheritance and intergenerational inheritance of the project. The younger generation of Zhangzhou Development Zone actively recorded and retained video materials, and publicized the humanistic feelings carried by “sending the king ship” by means of wechat, live broadcast and other new media.

“It was the older generation who did this before. Last year, the” send the king ship “successfully declared a world-class intangible cultural heritage, which made our younger generation realize the importance and urgency of protecting it. Under the leadership of our predecessors, we will do our part in inheriting it in our own way.” Zeng Minggui, a staff member of Baoquan palace, said.

Mansion

The “King ship” sailed to a new channel

Fujian Daily Reporter Lin Zegui

On the hand-made “King ship” with a length of more than 10 meters, colorful flags flutter, the painted dragons are vivid, and the paper people are also vivid… On the 19th, the triennial folk activity of “sending the king ship” was held in Shitang village, Songyu street, Haicang District, Xiamen, attracting thousands of people to participate. On November 28, fanghu society, Heshan street, Huli District, also held a 12-year “send the king ship” activity. Due to the requirements of epidemic prevention and control, the scale and links of the “King ship” between the two places have been reduced, but the scene is still very lively.

In the year when “send the king ship” was included in the list of representative works of intangible cultural heritage of mankind, more young people participated in ritual practice, and more “ship making” skills entered the campus. Relevant activities extended to cultural festivals, and even strive for activity space for the demolished villages… In Xiamen, the main application city, more and more representative communities and transmission sites paid more attention to its living inheritance and intergenerational inheritance, striving to write the new “ship” theory of Haisi culture.

Keep the temple and continue to inherit

“Such a characteristic folk activity with a long history is not only people’s Carnival in respect of the sea and their simple desire to pray for peace, but also maintains the feelings of overseas Chinese and their hometown. It must be well inherited!” On the 19th, Ji Changmei, a Nanping native who works and lives in Xiamen, said she was deeply shocked after watching the “King ship” in Shitang, Haicang.

As the central area of the belief of “sending the king ship”, the inheritance and dissemination of “sending the king ship” in Xiamen is the most typical in the contemporary era. At present, 13 communities and villages, including Xiagang, Tapu and Hecuo in Siming District, Pukou, Zhongzhai and fanghu in Huli District, Zhongshan, Shitang, Haicang and Xinlong in Haicang District, lvcuo in Tong’an District and Houcun in Xiang’an District, retain large-scale folk activities of “sending King ships”.

“The ‘King sending ships’ in these 13 places are similar. They are generally held every three or four years at the beginning of the northeast monsoon in autumn. Most of them have’ King welcoming and King sending ceremonies’.” Shi Yilong, a retired professor in the Department of Anthropology and Ethnology at Xiamen University, said that at the beginning of the ceremony, people gathered at the seaside to welcome the “Lord”

Zhao Liqiong publicized laws and regulations to the masses. Map provided by Anhui Provincial Department of transportation

Every autumn and winter, it is the busiest time for Zhao Liqiong, the leader of Wuwei Expressway in Anhui Province.

The section under the jurisdiction of the brigade has developed water system and frequent foggy weather, and traffic accidents are easy to happen to vehicles. In addition, the proportion of bridges in the jurisdiction section is high. In autumn and winter, in case of rain, snow and low temperature, the bridges and roads are easy to freeze, which makes it more difficult for the road administration team to deal with traffic accidents.

“I’m used to it. It’s our duty to ensure the safety and smoothness of the road.” After working on the expressway for 14 years, Zhao Liqiong has handled too many complex and urgent traffic accidents. No matter whether it is windy or rainy, whenever there is an emergency in the section under her jurisdiction, Zhao Liqiong is always the first to rush out and arrive at the scene with the team members at the first time to deal with the dangerous situation quickly, so as to provide guarantee for the safe travel of drivers and passengers.

Comrade Zhao Liqiong, the leader of the brigade, led the team members to carry out food safety inspection in the service area of the section under their jurisdiction. Map provided by Anhui Provincial Department of transportation

“Although she is a lesbian, she has more momentum at work than a gay man!” In the eyes of the team members, Zhao Liqiong is not only the “model woman” on the highway, but also the backbone of the whole team. At the beginning of 2020, COVID-19 broke out. In the face of the situation of too many highway crossings, too few staff and lack of protective materials, zhaoliqiong took the initiative to cancel her vacation and stuck to the front line with the team members. When the epidemic situation was the most severe, Zhao Liqiong and the team members were on duty 24 hours at the epidemic prevention and control detection points in the toll stations and service areas under the jurisdiction, publicized the basic knowledge of epidemic prevention and control to the past drivers and passengers, and called on everyone to actively cooperate with the party and the government in various epidemic prevention work.

After the epidemic situation stabilized, there were flood disasters in different degrees in southern Anhui. Zhao Liqiong cancelled her vacation again and turned to work in flood control. Together with the team members, she inspected the waterlogging prone areas in the sections under her jurisdiction. “The more fully prepared, the more calmly she can deal with emergencies.” Zhao Liqiong said that in her daily work, she and her team members simulated and handled a variety of emergencies and made full plans to ensure the safety and smoothness of the expressway under her jurisdiction and the safety of people’s lives and property.

After 14 years of hard work, Zhao Liqiong has always adhered to the life motto of “dedication without hardship and endless pursuit”. With her service-oriented work philosophy, honest and clean work style and realistic and pragmatic work attitude, she has engraved her original heart in her heart, carried the mission on her shoulder, implemented it in action, fulfilled her sonorous oath when joining the party with her work achievements, and shouldered the mission, worked hard and unswervingly in the new era, Write a new chapter of living up to the party and the people with heart and emotion.

On April 27, the reporter learned from the Henan Museum that the “May Day” holiday is coming. The Henan Museum is scheduled to resume its opening from April 29, 2022, and the Chinese ancient music Troupe will resume its performance from April 30. The Central Plains Sinology forum will not be held temporarily.

In order to do a good job in epidemic prevention and control and ensure the health and safety of the audience, Henan Museum will not receive the audience in the location of medium and high-risk areas and the audience with a history of living in the location of medium and high-risk areas within 14 days. All personnel should consciously wear masks during the admission visit, show the health code and travel code to the staff, and cooperate with the body temperature measurement. Visitors from areas outside the province should hold the negative certificate of nucleic acid test within 48 hours.

Henan Museum adopts the online real name reservation method. Visitors can make an appointment at different times through the wechat official account of Henan Museum. Those who do not make an appointment cannot enter the hospital area. Henan Museum will timely adjust the visiting measures according to the provincial and municipal epidemic prevention and control requirements. For detailed holiday visiting strategies, please pay attention to the official website, wechat official account, official microblog, etc. of Henan Museum to learn more about offline related information.

If you have any questions, you can call 0371-63511237 / 63511239 for consultation.

At 9:06, the Beijing Aerospace Flight Control Center issued a return command through the ground measurement and control station, and the orbital module of Shenzhou 13 manned spacecraft was successfully separated from the return module. At 9:30, the spacecraft returned to the brake engine and ignited, and the return module was separated from the propulsion module. After the successful landing of the re-entry module, the search and rescue unit responsible for the search, rescue and recovery task found the target in time and arrived at the landing site at the first time. After the return cabin door was opened, the medical supervision and medical insurance personnel confirmed that the astronauts were in good health. Relevant leaders of the mission headquarters of the manned space engineering space station phase greeted the astronauts at the Dongfeng landing site.

The Shenzhou 13 manned spacecraft was launched from the Jiuquan Satellite Launch Center on October 16, 2021, and then docked with the Tianhe core module to form a combination. Three astronauts entered the core module for a six-month stay, setting a new record for the continuous on orbit flight time of Chinese astronauts. During the astronauts’ in orbit flight, they successively carried out two out of cabin activities, carried out a number of scientific and technological practical (Trial) tests such as manual teleoperation rendezvous and docking and manipulator assisted cabin segment transposition, and verified the key technologies such as astronauts’ long-term residence support, regenerative life support, space material supply, out of cabin activities, out of cabin operation and in orbit maintenance. Taking advantage of the gap between missions, the astronauts also conducted two “Tiangong classroom” space lectures, as well as a series of distinctive popular science education and cultural communication activities.

The complete success of Shenzhou 13 manned mission marks the successful completion of the mission in the key technology verification stage of the space station, and the Chinese space station is about to enter the construction stage.

At the Haikou Branch venue, the large-scale UAV performance over Haikou Yundong library kicked off the activity that night. “Mountains and rivers are safe, the country is peaceful and the people are safe”, “2022, walk with you”, “ponder the year of China”, “add wings like a tiger” and a lifelike tiger over Yundong and century bridge have become a beautiful scenery for the new year this year, and present a UAV light show for the general public and tourists.

Looking at the light show shining in the night sky of Haikou, Mr. Li, a citizen of Haikou, said that Yundong is a popular punch in place. It’s so beautiful to play here and meet a beautiful light show that complements the beautiful Haikou Bay. Ms. Li, an old migratory bird from Beijing, said that Haikou has rich and colorful spring festival activities. When I met this light show, I felt that Haikou is a trendy city and a good place to spend the new year in winter. “Many of my friends come to Haikou for the new year.” Ms. Li said that after the construction of Hainan free trade port, Haikou, as the capital city of Hainan, has become more and more fashionable, with more and more food, drink, accommodation, shopping and entertainment.

When it comes to fashion, in Haikou China Resources N-power trend park that night, a trendsetter party was being staged. The on-site super burning music and dance, various interactive games and the delivery of exquisite gifts pushed the atmosphere to a climax.

According to the plan, in terms of land layout, the high-speed railway business district will increase the land for green space and square and public service facilities, so as to improve the urban environment and service level; In terms of spatial form, it has reduced the number of planned towers in the region, optimized the layout of towers, expanded the spacing of towers, further optimized the urban style and created a beautiful skyline with undulating rhythm; In terms of improving the function of the park, four functional areas are planned for the sports park, and various sports venues are centrally arranged to create a sports park with complete functions, popularity and green ecology.

“The Central Green Sports Park in the high-speed rail business district starts from jingguangdong street in the West and Huitong road in the East, including four areas on both sides of xinshengli street. It will build a large-scale open sports theme ecological park integrating citizens’ fitness, dynamic competitive sports, table tennis and sports culture display to meet the sports needs of citizens of all ages.” Yin Shiwei, head of the special class of the high-speed railway business district of the city development and investment group, said that in the future, here, you can find your favorite sports venues, such as table tennis, badminton, indoor tennis, football, basketball, gateball, rock climbing and skateboarding.

The urban renewal project of high-speed railway business district is located in the south of the provincial capital. The core area extends to Jiantong street in the East, Zhonghua street in the west, South Second Ring Road in the South and Tabei road in the north, covering an area of 3.6 square kilometers, involving 5366 mu of land in Qiaoxi and Yuhua administrative regions. In order to promote the construction of high-speed railway business district, the demolition work in this area has been accelerated. At present, 488 households in Qiaoxi District have completed the signing, delivery and relocation, and 5000 square meters of buildings have been demolished; 98 merchants in Yuhua District have moved out, the undocumented houses involved have been demolished, and other buildings are being demolished.

In promoting the relocation work, the main leaders of the relevant districts, the front-line command, adhere to people-oriented, preach to the residents the significance of the construction of high-speed railway business district to the development of our city, clarify the policies and compensation standards, the staff assisted in various relocation related matters, and did everything possible to help solve the problems in life, which received the support of the masses.

“Urban development and investment group and China Resources Land set up special classes and centralized office, settled in the urban construction project service guarantee center, strengthened coordination and linkage based on the advantages of the platform, and made every effort to promote the implementation of the project.” Yin Shiwei said that in combination with the current situation, the mode of “complementarity between public construction projects and commercial projects” is proposed, and the scheme of phased implementation is proposed for the construction of the area. The investment and construction of high-end residential projects and public welfare projects will be accelerated according to the development and construction sequence of “central reserve East No. 3 education in the southern residential area, national reserve No. 135 plot, Dongxu group and overhaul locomotive depot area”. At the same time, while giving full play to the advantages of urban development and investment group, we will make full use of the brand and scale advantages of China Resources Group to accelerate regional investment promotion and project construction.

Yin Shiwei said that in the next step, the group will pay close attention to deepening the specific implementation scheme of the project, make overall consideration and comprehensively coordinate the work of the urban renewal project of high-speed railway business district, and ensure the synchronous promotion of public welfare project construction and commercial project development; Ensure the linkage and docking of land acquisition and demolition, construction and investment promotion; Take the urban renewal project of high-speed railway business district as an overall artwork, and strive to build the “urban living room” of the provincial capital with “world pattern and international vision”.

Relevant reports

Turkish presidential spokesman: zelenski said he was ready to meet with Putin in Turkey (global network)

According to the latest news from Russian satellite news agency and Tass News Agency on the 6th, Ibrahim Kalin, spokesman of the Turkish president, said that during a telephone conversation with Turkish President Erdogan, Ukrainian President zelenski said that he was ready to meet with Russian President Vladimir Putin in Istanbul or Ankara.

According to the report, TRT Haber television in Turkey quoted news from Karin as saying: “during the call between Erdogan and Zelensky, Zelensky said that he was ready to meet with Russian President Vladimir Putin in Istanbul or Ankara, and the specific location depends on the wishes of the Russian president.”

According to the report, Erdogan said earlier that if he received a positive reply from Russian President Vladimir Putin, it was possible to hold a meeting between the leaders of Turkey, Russia and Ukraine in Ankara or Istanbul. The report also said that Erdogan plans to talk to Putin on the 6th local time.

The street outside the restaurant was empty and there was not even a trace of waste on the road to indicate that passers-by had passed. There was nowhere to see the door into the small restaurant, as if the people inside were trapped. The three customers in the restaurant meditated, and there seemed to be no topic to share with each other or with the waiter.

The lack of story elements and exquisite composition, coupled with its bearing significance, have made this painting not only depict a certain place, but also have a wide resonance and universal connotation.

Looking for light in the dark

“Nighthawk” has always been positioned as a landmark painting to express loneliness and alienation. This painting was created in 1942. When incandescent light was just used in the early 1940s, hope had mastered its characteristics and added this unnatural light to his work. The open streets, the silent people in the restaurants, and the cold incandescent color convey the loneliness of urban life. Although hope denied that he intended to release such signals in his paintings, he admitted that he may have subconsciously sketched a alienation between people in big cities. Indeed, it can evoke the eternal theme of loneliness, which may be one of the reasons why this painting has become a classic.

Many people may not know that Nighthawk is hope’s response to a generation of serious crises - Pearl Harbor on December 7, 1941, and World War II. In fact, Nighthawk alludes to the far-reaching psychological impact of World War II on Americans. Even in the rear area that has not been destroyed by the war, people’s mood is full of depression and anxiety.

In the 1940s, before the blackout in Times Square, New York

For fear of attack, New York conducted power outage exercises in public places, and the city lights were dimmed. Hope, who likes walking, is forced to walk around a city that is literally and figuratively shrouded in darkness. “Nighthawk” was inspired by a brightly lit restaurant he imagined one night.

From the perspective of hope’s experience in the war era, perhaps hope regards this brightly lit restaurant as a beacon of light and hope, rather than a place isolated from the outside; When everything outside is cruel and unbearable, a time to find a group in the dark. He purposefully includes four characters, not just a single character, which is not common in many of his other paintings.

The economic crisis in the United States in the 1930s made the prosperity and joy brought by the once rapidly developing capitalist economy ebb overnight, leaving only dry, anxious, desperate and thirsty. It was an uneasy era. People experienced sudden poverty and pain, but at the same time, they also kept asking questions, seeking answers and antidotes in different forms and media. This attitude of pursuit contributed to the eruption of American modern art in the same period.

The Nighthawk was purchased by the Chicago Museum of art in 1942 and has always been one of the most popular exhibits among visitors. Hope once mentioned in a letter to Daniel Catton rich, the then curator of the museum, “Nighthawk” is one of his “favorite works”.

Unidentified urban space

Modern urban life scene is Edward hope’s best visual theme. Many people try to find the actual location of Nighthawk in New York, but they get nothing. Perhaps hope has never deliberately copied any specific space. The restaurant in Nighthawk is probably a scene extracted from hope’s accumulated impression of life. The author’s experience in a restaurant is more real than that in a restaurant.

Like Nighthawk, there are three other works created by hope in the 1930s - New York movie, gas and early Sunday morning, which also let us feel the hope style expression in different scenes.

The New York cinema reflects the same creative principles. Hope began to work on this painting in December 1938. Before that, he experienced a long period of inspiration depletion. For this work, the artist visited all major cinemas in New York, including the strode theater, the universal theater and the Republic theater. Finally, he decided to stay at the Palace Theater (today’s lunt Fontana theater) on West 46th street for the initial sketch work, but the projection hall and corridor finally presented in the picture did not refer to the interior of any specific theater. It should be said that the scene in the painting is hope’s overall perception of the concept of “New York cinema”.

Edward hope, New York cinema, New York Museum of modern art

On the right side of the picture, leading to the exit of the projection hall, in the only corner illuminated by lights, stood an unidentified woman, who fell into meditation; The woman standing in the corridor seems to be the theme of the picture, compared with the shadows of the audience scattered in the dark projection hall on the left. The woman’s face is not clear, but her blonde hair and royal blue one-piece gown stand out. It is said that hope designed the clothes of the women in the painting by imitating the clothes of the female employees of the Palace Theater in New York, which can be said to be a re creation of the real visual elements. Hope’s wife, artist Jo hopper, is the prototype of the woman on the right side of the picture. She also appeared in Nighthawk.

The poet Joseph Stanton wrote a beautiful poem for this work, entitled Edward Hopper’s “New York movie”. The last section of the poem is as follows:

The picture tells us a lot about

Different quality

Melatonin is a hormone secreted in large quantities at night or in weak light. Its main function is to regulate the sleep wake cycle. So how do melatonin receptor genes and dinner time affect an individual’s blood glucose control? Is there any association between the risk of type 2 diabetes and the risk of type 2 diabetes?

Recently, researchers from the Harvard Medical School Massachusetts General Hospital (MGH) and the Brigham and Women (s Hospital, BWH) scholar, the joint research team from the United States and Spain explored this issue and published research results in the diabetes Journal (Diabetes Care). The results showed that: 1) 1 hours before bedtime (when endogenous melatonin level was high), eating supper resulted in low insulin secretion and impaired glucose tolerance, which increased the risk of type 2 diabetes. 2) Especially in individuals with melatonin receptor MTNR1B gene mutation, this risk is higher.

Previous studies have shown that melatonin receptor 1B gene (MTNR1B) can increase the risk of type 2 diabetes and gestational diabetes mellitus, which has been considered as a genetic bridge between circadian rhythm and glucose metabolism.

The purpose of this study is to explore whether carriers of type 2 diabetes related G alleles, especially in the MTNR1B gene, are involved in the increase of endogenous melatonin levels (such as before bedtime). The randomized crossover study included 845 Spanish adults aged 18 and -70 who had no diabetes history and no history of drug use.

The study set up two meal times: “early dinner group”, that is, eating dinner 4 hours before the regular sleep time; And “late dinner group”, i.e. eating dinner 1 hour before normal sleep time. All subjects were randomly divided into one group, then changed to another group on the other night, and then repeated the test of relevant indicators.

Eating dinner was simulated by an oral glucose tolerance test. After fasting for 8 hours, each subject took 75 grams of glucose beverage orally for the next two nights to simulate early and late eating. The glucose tolerance (blood glucose and insulin response) of the two groups of subjects within 2 hours after meal (every 30 minutes) and the difference between MTNR1B G allele carriers and non carriers were recorded.

Too late for dinner, poor blood glucose control

The research team found that,

Melatonin levels in the blood of subjects in the late dinner group were 3.5 times higher than those in the early dinner group.

Late dinner time also led to the area under the insulin curve (AUC), which is used to evaluate islets β The index of cell function) decreased by 6.7%, and the AUC of glucose increased by 8.3%, that is, the later the dinner time, the lower the insulin level and the higher the blood glucose level. The researchers say the association is reasonable because insulin reduces blood glucose levels.

Subjects with the MTNR1B G allele had higher blood glucose levels than those without this gene variant when they ate late at dinner. Genotypic differences in glucose tolerance were attributed to the MTNR1B G allele population β Decreased cell function.

The results showed that carbohydrate intake (a typical feature of late eating), especially MTNR1B G allele carriers, while endogenous melatonin levels increased, impaired blood glucose control, which could be attributed to defective insulin secretion.

Therefore, late dinner time increases the risk of diabetes.

Evidence for prevention of type 2 diabetes mellitus

“Our findings may be important for strategies to prevent type 2 diabetes.” Dr. Frank a.j.l. Scheer, CO senior author of the study and director of the BWh medical chronobiology program, said.

“The findings apply to about a third of the population in the industrialized world, including people who eat near bedtime, others who eat at night (including night shift workers, or those with jet lag and eating disorders), and people who use large amounts of melatonin supplements,” he added

The researchers point out that it is wise for the general population to fast at least four hours before going to bed.

Future exploration and Prospect

“Genotypic information on melatonin receptor variants may help develop individualized behavioral recommendations,” said Dr. Richa Saxena, lead researcher and senior author at MGH genomics medical center

She also stressed, “it is worth noting that our research does not include diabetes patients, so more research is needed to examine the effect of eating time in diabetic patients and its relationship with melatonin and genetic variation.”

Related reading

BMJ study of tens of millions of people: beware of high body mass index and thick waist! Increased risk of type 2 diabetes

ADA’s latest diabetes guideline: it is recommended that all people start screening at the age of 35. Metformin may not be the first choice. China’s diabetes mellitus 20 years study: high risk of cancer, obesity and blood glucose fluctuation are incentives. What kinds of cancer should we pay attention to? The compliance rate is less than 20%! AHA’s latest appeal: diabetics should pay attention to these 7 kinds of “heart care” strategies.

The depth of the Lancet: diabetes, sugar control concept to change! Three major indicators, two new technologies and four types of new therapies deserve attention

reference material

[1] Marta Garaulet， Jesus Lopez-Minguez， et al。， （2022）。 Interplay of Dinner Timing and MTNR1BType 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion： ARandomized

In order to meet personal vanity, a young man pretended to be a rich man and even engaged in “pranks”, using the p-chart applet to generate electronic vouchers for money transfer. He often ordered more than 100000 yuan of consumption bills, which eventually caused harmful consequences and was brought to justice. Recently, the Shenzhen Futian District procuratorate successfully sentenced a case of sabotage of production and operation, which was prosecuted according to law. The defendant Zhao was sentenced to 11 months’ imprisonment by the court.

It is understood that after investigation, at about 0 a.m. on March 7, 2021, the defendant Zhao came to a restaurant in Futian District, Shenzhen, lied that he would charter a birthday party during the day, and ordered Louis XIII, blue ribbon, VSOP and other precious foreign wines worth more than 260000 yuan. After that, a screenshot of false transfer was made through a map revision app, which was presented to the staff of the restaurant as a payment voucher, and then left under an excuse. After sending a message to the supplier, the staff of the dining bar found that the actual money had not arrived in the account for a long time, and found the revised app watermark on the transfer record picture, so they confirmed that they had been cheated and cancelled the purchase.

At about 21:00 that night, the defendant Zhao came to another bar and repeated his old technique. For the same reason, he ordered drinks and snacks worth more than 240000 yuan, such as Louis XIII, XO, red wine and whisky, and presented false transfer records to the bar staff. Then he left the bar under the pretext of leaving the bar. Later, the bar staff also found the watermark in time.

A few days later, the defendant Zhao came to a florist in Futian District, lied that 44 wedding cars needed to be arranged, ordered flowers worth more than 130000 yuan, presented false transfer records to the florist staff, and then left the florist under the pretext of leaving. Due to tight time and heavy workload, the florist immediately purchased a batch of flowers from the supplier and hired 11 temporary workers after receiving the order. After the order was made, Zhao couldn’t get the payment for the flowers, but he couldn’t be contacted until the order was made. Although the florist didn’t pay attention to the authenticity of the screenshot of electronic transfer, he also realized that he might be cheated, so he called the police. A large number of customized flowers are overstocked in the store and unsalable until they are discarded. Coupled with labor, fare and other costs, the florist has lost tens of thousands of yuan this time.

The defendant Zhao soon fell into the legal net. He said he was bored. In order to pretend to be handsome, satisfy vanity and make himself happy, he engaged in these pranks of “pretending to be a rich man” and swiping a luxurious bill. After examination, the prosecutor held that the defendant Zhao Mou ignored the national law, in order to pursue stimulation, meet personal desires, destroy the production and operation of others and cause property losses to others. His behavior has violated Article 276 of the criminal law of the people’s Republic of China. The criminal facts are clear, the evidence is reliable and sufficient, and his criminal responsibility should be investigated for the crime of destroying production and operation, Prosecute according to law. The Court adopted the public prosecution opinion of the procuratorial organ, found that the defendant Zhao was convicted of the crime of undermining production and operation, and sentenced him to fixed-term imprisonment of 11 months.

The prosecutor reminded: Zhao’s “prank” goes beyond the legal limit and constitutes a crime. While harming the interests of others, he will also be severely punished by the law. In the era of the prevalence of map revision, small and micro enterprise operators and citizens should always have a sense of prevention in the process of capital flow. They must carefully review the authenticity of transactions. After discovering similar situations, they should not just calm down, but also call the police in time to protect their rights and interests and prevent the wanton spread of such “small evils”.

Introduction:

Remember Zhao Dan, the flag bearer of the Chinese delegation at the opening ceremony of the Beijing Winter Olympic Games? It’s the 19-year-old steel snowmobile athlete. The reporter went to the national snowmobile and sleigh center in Yanqing competition area to cheer for China’s snowmobile and sleigh athletes. (edited by reporter Huang Qiyuan and Zhang Xiaoji)