In recent years, the role of the industrial internet in promoting industrial transformation and efficiency gains has continued, and the industrial Internet, as a new strategic infrastructure for industrialization, has become a key base for the deep integration of the digital economy and the real economy.

According to the data released earlier by the Ministry of Industry and Informationization, the industrial Internet has covered 45 major categories of 166 of the national economy, covering more than 85 per cent of the industrial category; the core industry of the industry is more than 120 million yuan, representing a 15.5 per cent increase over the previous year; and a system of multi-level industrial Internet platforms that are integrated, characterised and professional, with a focus on platform connectivity of more than 81 million units (set).

Universal interconnectivity is a prerequisite for all of this, and the foundation for the interconnectivity is the marking of “van objects”, i.e., industrial Internet marking. The Industrial InterNetwork system, which is an important component of the new infrastructure of the industrial Internet, is the “nervous system” of the industrial Internet, and plays an important role in promoting inter-industrial internet inter-systems, cross-linkages, cross-border inter-territory interconnectivity. The National Four Fourteen Five-Year Plan outlines the need for an autonomous and controlled marking system.

“The country has made positive progress in recent years with regard to its industrial internet marking system, which has never been available, small to large.” Wang Peng, Inspector-General at the level of the Information Communications Authority of the Ministry of Industry and Informationization. Currently, industrial Internet logo has been fully integrated into industrial enterprises’ research and development, procurement, production, warehousing, logistics, marketing links, generating value outside the enterprise, helping industrial enterprises to upgrade product quality, improve management efficiency, promote model innovation, and digitize and intelligent industrial enterprises.

According to data released at the China Industrial InterNetwork Congress in 2023, the national top-level node system of the Industrial Internet Identification System, “5+2”, has now been fully completed, with 284 top-level secondary nodes throughout the country, with full coverage of 31 provinces, districts and municipalities throughout the country, with cumulative marking registrations exceeding 26 billion.

“The mark is the entry point for the entire data, which, through our marker data, enables the establishment of the entire coding and marking system and the flow of data between the enterprise-wide product cycle, the downstream product chain and the service chain to generate value for the flow of industrial data.” The Chief Engineer of the China Institute of Information and Communications Technology made a statement.

Currently, marking applications cover 40 industries, such as automobile manufacturing, equipment manufacturing, electronic information, steel and steel, resulting in nine models, more than 20 typical applications, with a preliminary application system. The results of active marking applications are initially visible, and active marking carriers have deployed 2.12 million to collect data on indoor heat measurement forms, indoor gas form data collection, industrial sensor data collection, etc.

“Industry Internet Identification System enables data interchange between upstream and downstream machines and between downstream industrial chains.” It has been stated that, for example, at the procurement chain, suppliers’ orders, contracts, requirements, etc. are marked, at the warehouse logistics chain, at the warehouse area, at personnel, single prices, etc., and in order to improve efficiency in the movement of goods through upstream and downstream data.

“In the next step, we need to build an intelligent system for cooperative human resource management decision-making, transform the underlying equipment and production processes into a system of intellectual autonomy, with a view to achieving full optimization of manufacturing processes and individual customization of efficiency.” The Chinese Academy of Engineering, a non-casher, stated that we now rely more on people’s observations and later on data-driven, real-time monitoring and AI-system-based job profiles.

Currently, our industrial Internet is entering a critical stage of scale development, and the master engineer of the Ministry of Industry and Information, the press spokesperson, the State of Qatar, at a press conference held by the former Department of State press office, indicated that, next, the Ministry will actively promote industrial chain, supply chain and industrial interoperability. Focus industries, the development of guidelines for the integration of industrial Internet with priority sectors such as electronic information, engineering machinery, the promotion of marking “cross-the-board” actions, and the promotion of the popularization of industrial internets in priority industrial chains.

Building a well-developed industrial Internet “nerve system” continues to be driven by policy orientation and market demand. Strengthening the suitability of the marking system and enterprise information systems, industrial Internet platforms, industrial APP, etc., as well as the development of model bids for industrial Internet marking applications, and promoting accelerated extension of marking applications to more vertical areas.

In Beijing on 11 April, the Korean bride, Lee, was staggered during the women’s Korean curtain war, and the world was ranking by 222.

Lee, who was ranked in 13 public occupants, received 1.58 points and the world ranking rose from 869 to 647.

Ruo took part in the public competition of the women of the daily greetings of the Félix-Eritre Building, which was successfully promoted and ranked 53, with 0.36 minutes, a drop in the world ranking and 131 places.

Others are natural changes. After LPGA was seized, the world was ranked two times more, at 30 places.

Let us look at the sharp drop in the top 10 world rankings of Chinese women:

Linhia, 17

殷, 30 (+2, ↑)

Rutan, 131 (-1, ↓)

Stone, 140 (+4, ↑)

Liu Daqun, 185 (-4, V)

Hungi, 210 (+1, ↑)

Liu Ryan, 251

殷, 266 (-2, ↓)

Liches, 279 (-1, ↓)

Liu Daqun, 286 (+2, UPU)

Recently, Li Ning Sports (Shanghai) Co., Ltd. has applied for the registration of the trademark “Ning coffee”, officially announcing its entry into the coffee industry.

Should the leader of sports brand “Guochao” layout the coffee market? For a time, it has aroused widespread concern in the industry. There are different opinions on whether to play tickets or test the water. According to some insiders, coffee is more “embellishment” stores for Li Ning group, but others believe that this is opening up a new track.

During the discussion, Li Ning’s official response said: the company pays attention to the consumer purchase experience of retail terminals, hopes to improve customers’ comfort and experience during shopping by optimizing in store services, and provide coffee services in the store, which will be an innovative attempt of Li Ning for the consumer experience of retail terminals.

From the official response, coffee for Li Ning is more about improving the store experience than trying to open up a new track.

First of all, from a market perspective, coffee is one of the hottest consumption tracks in recent years. According to the data, in 2021, the scale of China’s coffee market was about 381.7 billion yuan. Some institutions predict that by 2025, the scale of the domestic coffee market will reach 1 trillion yuan, with a growth rate of 27.2%, far exceeding the global average of 2%. Facing the fast-growing track, capital has already poured in. According to data, from 2013 to 2021, coffee related projects were financed 114 times, with a disclosed amount of more than 11.5 billion yuan. Whether in terms of market scale or financing performance, the coffee track is worth Li Ning’s try.

Secondly, from the development stage, as an emerging industry, China’s coffee market is still in a relatively early stage. There are many domestic coffee brands. Starbucks, Tim Hortons, Costa and other international chain coffee brands are positioned as slow coffee scenes, focusing on the third space social networking; The “slow coffee camp” represented by% Arabica, m stand and seesaw is more about building brand awareness through stores, paying attention to the creation of aesthetic atmosphere, and taking high-quality coffee as its own; Novartis coffee, Ruixing coffee and man coffee are the representatives of high price coffee. The “fast coffee scene” is used to meet the needs of people who take coffee as their daily needs, and take the cost-effective route.

In addition, there are also some new cross-border players. Many industry giants such as “two barrels of oil”, China Post, Wanda, Tongrentang and even Goubuli have been involved in the coffee business one after another. In 2018, PetroChina established “Kunlun hospitality coffee” and sold freshly ground coffee in its Kunlun hospitality convenience store. In 2021, “hospitable coffee” opened more than 120 stores in 20 provinces and cities, with sales of more than 100 million yuan. The product line includes freshly ground coffee and ready to drink coffee. In 2019, Sinopec Yijie convenience store with nearly 30000 stores released a new brand “Yijie coffee”. In October 2019, Tongrentang Health Pharmaceutical Group’s new retail brand “Zhima health” experience store opened and launched medlar latte, Luohanguo American style and other “herbal” coffee. In February 2022, China Post announced that the country’s first post office coffee shop would officially land in Xiamen. On February 23, Tianjin “Goubuli steamed stuffed bun” also announced its entry into the Bureau and established gaoleya coffee.

What are Li Ning’s advantages in choosing to cross into the coffee track at this time? First, the number of stores. Compared with Ruixing with 6024 stores, Starbucks with 5654 stores in China and Nova coffee with more than 1500 stores in the same period, Li Ning coffee with more than 7000 outlets has certain advantages in scale. Once fully or partially launched, it is a force that can not be underestimated.

Secondly, different from the brand positioning of professional coffee making, the core logic behind Li Ning’s move is more similar to the business idea of resource reuse or new satisfaction of traffic. By improving the store experience, attracting young consumer groups and approaching generation Z, Li Ning’s national fashion image of China is strengthened.

Insiders pointed out that for brand entities, building scenes that consumers can experience and deeply perceive in time will become a key measure of market competition in the future.

As for whether this decision can really consolidate the brand barrier and become a new driving force for enterprises to move forward, it takes time to give the final answer.

Melatonin is a hormone secreted in large quantities at night or in weak light. Its main function is to regulate the sleep wake cycle. So how do melatonin receptor genes and dinner time affect an individual’s blood glucose control? Is there any association between the risk of type 2 diabetes and the risk of type 2 diabetes?

Recently, researchers from the Harvard Medical School Massachusetts General Hospital (MGH) and the Brigham and Women (s Hospital, BWH) scholar, the joint research team from the United States and Spain explored this issue and published research results in the diabetes Journal (Diabetes Care). The results showed that: 1) 1 hours before bedtime (when endogenous melatonin level was high), eating supper resulted in low insulin secretion and impaired glucose tolerance, which increased the risk of type 2 diabetes. 2) Especially in individuals with melatonin receptor MTNR1B gene mutation, this risk is higher.

Previous studies have shown that melatonin receptor 1B gene (MTNR1B) can increase the risk of type 2 diabetes and gestational diabetes mellitus, which has been considered as a genetic bridge between circadian rhythm and glucose metabolism.

The purpose of this study is to explore whether carriers of type 2 diabetes related G alleles, especially in the MTNR1B gene, are involved in the increase of endogenous melatonin levels (such as before bedtime). The randomized crossover study included 845 Spanish adults aged 18 and -70 who had no diabetes history and no history of drug use.

The study set up two meal times: “early dinner group”, that is, eating dinner 4 hours before the regular sleep time; And “late dinner group”, i.e. eating dinner 1 hour before normal sleep time. All subjects were randomly divided into one group, then changed to another group on the other night, and then repeated the test of relevant indicators.

Eating dinner was simulated by an oral glucose tolerance test. After fasting for 8 hours, each subject took 75 grams of glucose beverage orally for the next two nights to simulate early and late eating. The glucose tolerance (blood glucose and insulin response) of the two groups of subjects within 2 hours after meal (every 30 minutes) and the difference between MTNR1B G allele carriers and non carriers were recorded.

Too late for dinner, poor blood glucose control

The research team found that,

Melatonin levels in the blood of subjects in the late dinner group were 3.5 times higher than those in the early dinner group.

Late dinner time also led to the area under the insulin curve (AUC), which is used to evaluate islets β The index of cell function) decreased by 6.7%, and the AUC of glucose increased by 8.3%, that is, the later the dinner time, the lower the insulin level and the higher the blood glucose level. The researchers say the association is reasonable because insulin reduces blood glucose levels.

Subjects with the MTNR1B G allele had higher blood glucose levels than those without this gene variant when they ate late at dinner. Genotypic differences in glucose tolerance were attributed to the MTNR1B G allele population β Decreased cell function.

The results showed that carbohydrate intake (a typical feature of late eating), especially MTNR1B G allele carriers, while endogenous melatonin levels increased, impaired blood glucose control, which could be attributed to defective insulin secretion.

Therefore, late dinner time increases the risk of diabetes.

Evidence for prevention of type 2 diabetes mellitus

“Our findings may be important for strategies to prevent type 2 diabetes.” Dr. Frank a.j.l. Scheer, CO senior author of the study and director of the BWh medical chronobiology program, said.

“The findings apply to about a third of the population in the industrialized world, including people who eat near bedtime, others who eat at night (including night shift workers, or those with jet lag and eating disorders), and people who use large amounts of melatonin supplements,” he added

The researchers point out that it is wise for the general population to fast at least four hours before going to bed.

Future exploration and Prospect

“Genotypic information on melatonin receptor variants may help develop individualized behavioral recommendations,” said Dr. Richa Saxena, lead researcher and senior author at MGH genomics medical center

She also stressed, “it is worth noting that our research does not include diabetes patients, so more research is needed to examine the effect of eating time in diabetic patients and its relationship with melatonin and genetic variation.”

Related reading

BMJ study of tens of millions of people: beware of high body mass index and thick waist! Increased risk of type 2 diabetes

ADA’s latest diabetes guideline: it is recommended that all people start screening at the age of 35. Metformin may not be the first choice. China’s diabetes mellitus 20 years study: high risk of cancer, obesity and blood glucose fluctuation are incentives. What kinds of cancer should we pay attention to? The compliance rate is less than 20%! AHA’s latest appeal: diabetics should pay attention to these 7 kinds of “heart care” strategies.

The depth of the Lancet: diabetes, sugar control concept to change! Three major indicators, two new technologies and four types of new therapies deserve attention

reference material

[1] Marta Garaulet， Jesus Lopez-Minguez， et al。， （2022）。 Interplay of Dinner Timing and MTNR1BType 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion： ARandomized

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