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            <title><![CDATA[pump.Science Launches E-commerce Store, Debuts First-Ever Tokenized Supplement ]]></title>
            <link>https://paragraph.com/@pump-science/pump-science-launches-e-commerce-store-debuts-first-ever-tokenized-supplement</link>
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            <pubDate>Thu, 20 Mar 2025 14:03:10 GMT</pubDate>
            <description><![CDATA[Crypto-Powered Research Now Fuels Real Products—The Flywheel is Complete Every game has a final level—the moment where the grind makes sense, the mission is clear, and you realize what you have been building toward all along. Since day one, pump.science had one vision: enabling crypto traders to create scientific breakthroughs and breakthroughs into usable products. Today, that vision becomes reality. The pump.science e-commerce store is officially open, and the first-ever tokenized supplemen...]]></description>
            <content:encoded><![CDATA[<p><em>Crypto-Powered Research Now Fuels Real Products—The Flywheel is Complete</em></p><p>Every game has a final level—the moment where the grind makes sense, the mission is clear, and you realize what you have been building toward all along.</p><p>Since day one, <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="http://pump.science/">pump.science</a> had one vision: enabling crypto traders to create scientific breakthroughs and breakthroughs into usable products.</p><p>Today, that vision becomes reality.</p><p>The pump.science <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://shop.pump.science/">e-commerce store</a> is officially open, and the first-ever tokenized supplement, <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://shop.pump.science/products/urolithin-a">Urolithin A</a>, is available for preorder.</p><h1 id="h-crypto-research-meets-real-world-products" class="text-4xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0">Crypto Research Meets Real-World Products</h1><p>What’s a tokenized supplement? It’s a real product, powered by real research. Instead of big supplement companies running things, pump.science lets the market decide which compounds are worth testing. Crypto trading funds research, research finds the best longevity compounds, and those compounds turn into real supplements you can actually use, all while creating infrastructure for tokenholders.</p><h2 id="h-why-it-matters" class="text-3xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0">Why It Matters</h2><p>You may be taking a handful of supplements, but do they actually work? Unlike most companies creating products for customers behind closed doors, pump.science creates products alongside customers and executes experiments completely open-source. Here’s how the process works:</p><ul><li><p><strong>Crypto trading funds the research:</strong> The community determines which compounds are researched.</p></li><li><p><strong>Open Data Guides Development:</strong> Experimental data determines the strongest longevity compounds</p></li><li><p><strong>Compounds Become Products:</strong> Those compounds become the final products sold on the pump.science store, fueling an onchain research and development ecosystem.</p></li></ul><p>Every piece of the pump.science vision is now in place. For the first time, crypto is powering tangible, scientifically validated products. This means you’re not just buying a product; you’re actively participating in the next evolution of discovery and innovation.</p><p>Rather than trust that the products you are taking actually work, you can directly verify, and even participate in the discovery process. While many write off crypto as a scam, pump.science is actively using the technology to validate and bring products to market that improve health and wellness.</p><h1 id="h-urolithin-a-a-longevity-cheat-code" class="text-4xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0">Urolithin A: A Longevity Cheat Code</h1><figure float="none" data-type="figure" class="img-center" style="max-width: null;"><img src="https://storage.googleapis.com/papyrus_images/5c7adad772b34d57ac548dac5ea96d9a071a7ae426d67d05fa58b17cfbd312a7.png" alt="" blurdataurl="data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACwAAAAAAQABAAACAkQBADs=" nextheight="600" nextwidth="800" class="image-node embed"><figcaption HTMLAttributes="[object Object]" class="hide-figcaption"></figcaption></figure><p>Every compound token on pump.science must prove itself through a rigorous research process. To advance through each research level, a compound must:</p><ol><li><p>Pass safety checks—no harm to the test organisms</p></li><li><p>Secure enough funding to execute further experiments that prove its impact on longevity</p></li><li><p>Demonstrate that it does not harm longevity in animals</p></li></ol><p><a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://pump.science/experiments/URO?mint=FvgqHMfL9yn39V79huDPy3YUNDoYJpuLWng2JfmQpump&amp;exp=9ae1e48c-d459-4d1a-9bad-8eb0b2ee6d96">Urolithin A</a> is one of the first molecules put to the test. Let’s take a look at the early results:</p><ul><li><p>Level 1: Worms → Lifespan increased by 6.35%</p></li><li><p>Level 2: Flies →  Lifespan increased by 20.13%</p></li><li><p>Level 3 Mice → Endurance studies underway</p></li><li><p>Level 4 Humans → Starting soon</p></li></ul><p>Urolithin A demonstrated that it can extend experiment the lifespan of worms and flies, but it is certainly still early.</p><p>Now, the first crypto-backed supplement has officially moved from the lab into your hands.</p><h2 id="h-why-supplement-with-urolithin-a" class="text-3xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0">Why Supplement with Urolithin A?</h2><figure float="none" data-type="figure" class="img-center" style="max-width: null;"><img src="https://storage.googleapis.com/papyrus_images/86637eb3d7aa5726d4150d4da846bc0fa31558ad15a27b427a9414392d43a619.jpg" alt="" blurdataurl="data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACwAAAAAAQABAAACAkQBADs=" nextheight="600" nextwidth="800" class="image-node embed"><figcaption HTMLAttributes="[object Object]" class="hide-figcaption"></figcaption></figure><p>Your mitochondria—the powerhouse of your cells—accrue damage as you age. Damaged mitochondria means lower energy, slower recovery, and faster aging.</p><p>Your body has a built-in recycling system: mitophagy, which cleans out broken mitochondria and replaces them with fresh ones. The issue? Mitophagy slows down as you get older.</p><p>Urolithin A reignites mitophagy, recycling, and revitalizing the powerhouses.</p><p>Certain ingredients in foods like pomegranates can be converted to Urolithin A by some, but not all, leaving many without the ability to get Urolithin A from natural sources. The only guaranteed way to get Urolithin A into your cells? Supplementation.</p><h1 id="h-preorder-urolithin-a-and-join-the-human-study" class="text-4xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0">Preorder Urolithin A &amp; Join the Human Study</h1><p>Urolithin A preorders are now live:</p><ul><li><p>Preorder now from <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://shop.pump.science">shop.pump.science</a></p></li><li><p>Crypto-only payment (Solana Pay)</p></li><li><p>First batch shipping soon</p></li></ul><figure float="none" data-type="figure" class="img-center" style="max-width: null;"><img src="https://storage.googleapis.com/papyrus_images/6853f7a9330d719d90bd64121027c1b468c4e867c97f3844632a4420f2207a1e.jpg" alt="" blurdataurl="data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACwAAAAAAQABAAACAkQBADs=" nextheight="600" nextwidth="800" class="image-node embed"><figcaption HTMLAttributes="[object Object]" class="hide-figcaption"></figcaption></figure><p>If you subscribe to a 3-month supply and have a wearable device (Garmin, Apple Watch, Whoop, or soon-to-be Pulse)— you may be eligible to join the <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://mirror.xyz/0xbe44A79FBF6f42455559C8b6D1cBBa109BaF3F10/cw9xVYnA1JeG63Q-yF02XyATFTT9OpNLKZULVbKt_-4">pump.science x Pulse </a>decentralized real-world human study to test Urolithin A’s impact.</p><p>Participants will:</p><ul><li><p>Take Urolithin A daily at a specified dose.</p></li><li><p>Track longevity biomarkers (VO₂ max, HRV, sleep) with wearables.</p></li><li><p>Get first access to the supplement.</p></li><li><p>Earn token rewards for hitting milestones.</p></li></ul><p>Don&apos;t just take the product—help shape it. Subscribe to a 3 month supply of Urolithin A <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://shop.pump.science">here</a>.</p><p>The first supplement is available. And now the flywheel is turning.</p><p>Welcome to the future of longevity.</p><p>Play harder. Live Longer.</p><h2 id="h-about-pumpscience" class="text-3xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0">About pump.science</h2><p><a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://pump.science/">pump.science</a> is a crypto-powered research protocol for launching and funding scientific experiments, starting with longevity studies. Born in the trenches of DeSci, the protocol enables users to launch compound tokens, fund real scientific experiments through trading fees, and watch research unfold in real-time—from worm studies to human trials. pump.science is making science self-custodial, transparent, and maximally degen. For more information, visit <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://pump.science/">pump.science</a> or follow us on <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://x.com/pumpdotscience">X</a>.</p>]]></content:encoded>
            <author>pump-science@newsletter.paragraph.com (pump.science)</author>
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            <title><![CDATA[Launch Your Own Longevity Experiment—Test Your Supplements & Shape the Future of Science]]></title>
            <link>https://paragraph.com/@pump-science/launch-your-own-longevity-experiment-test-your-supplements-shape-the-future-of-science</link>
            <guid>LxKiYw4WpdkZ0OIUlAe7</guid>
            <pubDate>Wed, 19 Mar 2025 06:39:15 GMT</pubDate>
            <description><![CDATA[Are the supplements you are taking really doing anything? What if the power to answer this question was in your hands? Most groundbreaking discoveries started as questions no one else was daring—or willing—to answer. Maybe you have a hunch about a certain herb or compound you’ve tried. Perhaps you’re convinced there’s more to some overlooked substance. This is your moment to get real data, shape public understanding, and possibly bring to market what truly works for health and longevity. pump...]]></description>
            <content:encoded><![CDATA[<p>Are the supplements you are taking really doing anything? <em>What if the power to answer this question was in your hands?</em> Most groundbreaking discoveries started as questions no one else was daring—or willing—to answer. Maybe you have a hunch about a certain herb or compound you’ve tried. Perhaps you’re convinced there’s more to some overlooked substance. This is your moment to get real data, shape public understanding, and possibly bring to market what truly works for health and longevity.</p><p>pump.science creates a way for you, personally, to run scientific experiments on your favorite supplements, and find out whether they have the potential to change lives.</p><p>At pump.science, we’re pioneering a new model where anyone can directly fuel, shape, and benefit from scientific research, and we want you to be a part of it. More ideas means more potential breakthroughs in health and longevity. Who knows? Maybe you have the idea for the next magic molecule that goes viral.</p><hr><h2 id="h-ready-to-launch-your-experiment" class="text-3xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0">Ready to Launch Your Experiment?</h2><ol><li><p><strong>Pay 3 SOL (~$373.61 USD)</strong> to start a lifespan experiment on worms (C. elegans)</p><ul><li><p>If your compound is disqualified (known toxin, not commercially available, patented, etc.), you’ll receive a full refund.</p></li></ul></li><li><p><strong>Submit One or Two Compounds</strong>—test them alone or in combination.</p></li><li><p><strong>Lab Testing Begins:</strong></p><ul><li><p>For <strong>worms</strong> (C. elegans), 60 animals receive your compound, and 60 serve as controls to measure longevity.</p></li><li><p>For <strong>flies (Drosophila)</strong>, 15 get your compound, 15 are controls, and we track speed, endurance, and lifespan.</p></li><li><p>For <strong>mice</strong>, 3 get your compound, and 3 are controls, and we track endurance.</p></li><li><p>For <strong>humans</strong>, 200 get your compound at 4 different dosages.</p></li></ul></li><li><p><strong>Get your results</strong> within several weeks.</p></li><li><p><strong>Launch a token</strong> that holds the intellectual property rights to your compound.</p></li><li><p><strong>Buy 5% of your token supply for 1.5 SOL (~$186.77 USD).</strong></p><ul><li><p>If your token reaches 303 SOL (~$38k) market cap, you reclaim your 3 SOL deposit.</p></li><li><p>You’ll also earn <strong>5% of all trading fees—forever</strong>.</p></li><li><p>These trading fees help fund more experiments, multiplying the impact of your idea.</p></li></ul></li><li><p>We can help you sell your compound</p></li></ol><hr><h2 id="h-ground-rules" class="text-3xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0">Ground Rules</h2><ul><li><p><strong>No known toxins or hazardous chemicals</strong></p></li><li><p><strong>Must be commercially available</strong> (from <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://www.sigmaaldrich.com/">Sigma</a>, <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://www.medchemexpress.com/">MedchemExpress</a>, or <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://www.apexbt.com/">Apex Bio</a>)</p></li><li><p><strong>Cannot be patented</strong> (Use Grok or ChatGPT to check)</p></li><li><p><strong>Cannot be an illegal or controlled substance</strong></p></li></ul><hr><h2 id="h-let-out-your-inner-scientist" class="text-3xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0">Let Out Your Inner Scientist</h2><p>Real science doesn’t have to stay locked behind university walls or corporate pipelines. We’re opening the doors for you to participate in the kind of research that can not only contribute to scientific knowledge but directly improve lives.</p><p><strong>Submit your compound idea </strong><a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://moleculeprotocol.typeform.com/to/BETUBrL8#source=lab+is+open+blog"><strong>here</strong></a>. <em>It’s first come, first serve, and whoever submits ideas first claims them.</em></p>]]></content:encoded>
            <author>pump-science@newsletter.paragraph.com (pump.science)</author>
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            <title><![CDATA[pump science: Accelerating Longevity Research and Bringing DeSci to the Masses]]></title>
            <link>https://paragraph.com/@pump-science/pump-science-accelerating-longevity-research-and-bringing-desci-to-the-masses</link>
            <guid>JN8XIV2LI1ZdZ4ManENd</guid>
            <pubDate>Tue, 18 Feb 2025 18:55:17 GMT</pubDate>
            <description><![CDATA[Life is the ultimate multiplayer game. We’re all playing whether we choose to or not. One life and our health points only go down. The truth is, the game doesn’t want us to win. The players who came before us have rigged the game to pump their bags at the expense of our bags and lives. Though the game is getting more advanced, it is not necessarily in our favor. There’s only one way to take it back: by force. Do you want to live your best life? Do you want to play the game for longer? Do you ...]]></description>
            <content:encoded><![CDATA[<p>Life is the ultimate multiplayer game. We’re all playing whether we choose to or not. One life and our health points only go down. The truth is, the game doesn’t want us to win. The players who came before us have rigged the game to pump their bags at the expense of our bags and lives. Though the game is getting more advanced, it is not necessarily in our favor. There’s only one way to take it back: by force. Do you want to live your best life? Do you want to play the game for longer? Do you want to play, or are you okay with sitting back and getting played?</p><p><strong>pump science</strong> was founded on the belief that we can rewrite the rules of healthcare. We don’t just believe we can live longer, healthier lives— we’re proving that people are ready to take control from a system that profits from their decline, and decentralized science (DeSci) is our weapon of mass production. After spending years building in DeSci, we’ve seen firsthand where the space is currently stalled: small user bases, complicated research pathways, and friction from legacy institutions. <strong>pump science</strong> is our answer— a protocol designed to overcome these hurdles and finally deliver on the promise of DeSci. Here is how we are changing the game.</p><h2 id="h-1-more-players" class="text-3xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0"><strong>1. More players</strong></h2><p>Until now, DeSci has been trapped in an echo chamber — sustained by a tiny intersection of crypto users and science enthusiasts. Even among those, funding often depended on one-off whale contributions rather than a core group of passionate, long-term supporters. Over time, enthusiasm waned because the game lacked staying power; it wasn’t obvious what people were supposed to <em>do</em> with a token with nebulous utility, tied to obscure research that wasn’t advancing fast enough.</p><p>pump science takes crypto’s superpower—<strong>trading</strong>—and uses it as fuel for something bigger: human longevity. Each token on pump science represents a compound that could extend life itself. We let traders do what they do best: hunt for gems. The difference is that every trade funds research pushing the ceiling of our lifespans. Instead of waiting endlessly for an abstract payoff, degens can manifest near-term biotech products in the form of longevity supplements.</p><h1 id="h-2-making-the-game-fun" class="text-4xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0"><strong>2. Making the game fun</strong></h1><p>Most DeSci projects fund highly technical deep science. For most crypto users, this is like jumping straight to advanced mode. Without a tutorial or a beginner mode, most players don’t even try to play, and eventually stop caring about a game they don’t know how to win.</p><p>pump science simplifies the game and focuses on something everyone understands: survival. Compounds make animals either live longer or they don&apos;t. Rather than waiting months to see the research results, pump science users can watch experiments <strong>as they happen</strong>, tracking survival outcomes in real time. This creates constant material for trading, discussion, and community-building—turning scientific experiments into a game anyone can play.</p><h1 id="h-3-accelerating-the-game" class="text-4xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0"><strong>3. Accelerating the game</strong></h1><p>DeSci has accelerated funding, but those funds are still rate limited by the friction and bureaucracy of academia. Once you have convinced an academic scientist (PI) to accept funding for their project, you must then negotiate with the university’s technology transfer office (TTO) to fund their lab. TTOs are notoriously slow and risk-averse, often stalling deals that touch crypto. This friction kills momentum and drains any small DeSci project’s limited resources.</p><p>pump science leverages <strong>contract research organizations (CROs)</strong>, which operate on clear, transactional agreements. CROs are accustomed to industrial data protocols, can onboard new clients quickly, and can often ship data at whatever cadence a client requests. Experiments can be launched in days and streamed in real-time. For a fledgling DeSci industry where time and attention are scarce, CROs are clearly the more optimal scientific execution layer relative to academia.</p><h1 id="h-4-keeping-score" class="text-4xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0"><strong>4. Keeping score</strong></h1><p>Academic labs often withhold data, with an incentive to shape a compelling narrative suitable for publication. Data formats vary widely from lab to lab and student to student. Grad student data outputs are most likely nightmare fuel for a seasoned data engineer. The data submission by an academic lab is typically delayed, inconsistent, and incomplete.</p><p>pump science pushes radical openness of scientific data. Without being beholden to publication or data monetization, we can make the data wide open in the accelerationist pursuit of life extension. Every data point streamed for all to see. Our CROs have <strong>no incentive</strong> to alter or withhold data. Their reputation depends on delivering accurate, standardized results to clients on schedule. This is crucial for building AI pipelines that thrive on structured, high-quality datasets. By engaging CROs, we can <strong>guarantee timely, uniform data outputs</strong>, accelerating both analysis and the potential for real-time decision-making.</p><h1 id="h-5-coins-with-actual-utility" class="text-4xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0"><strong>5. Coins with actual utility</strong></h1><p>DeSci tokens to date have typically offered weak value propositions: DAO governance tokens that rarely yield actual power, or IP tokens tied to uncertain, far-future payouts if big pharma happens to buy the research. Neither resonates with mainstream crypto traders who prefer clear, near-term ROI.</p><p>pump science tokens are directly tied to <strong>supplements</strong>—products that can be commercialized much faster than novel pharmaceuticals. If a compound shows promise in animal models, we can move quickly to sell it as a supplement (where regulations are more lenient than for prescription drugs). Revenue from supplement sales can be used to <strong>buy back and burn</strong> the associated token, creating immediate and tangible value for token holders. This model also incentivizes community members to promote the product—just as they would any token—because stronger product sales mean direct token appreciation. With this, twitter token shilling armies turn into supplement sales armies.</p><h1 id="h-6-ping-time" class="text-4xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0"><strong>6. Ping time</strong></h1><p>Which blockchain we build pump.science on will undoubtedly shift its probability of success. In an ideal world, DeSci and AI innovations should thrive on a platform that makes onboarding and day-to-day use as simple as possible. <strong>Ethereum</strong>, while foundational, is still cumbersome for newcomers: complex onboarding flows, high gas fees, and slow transaction times undermine mass adoption.</p><p>Solana, in contrast, has <strong>faster transaction speeds, near-zero fees, and a more user-friendly onboarding experience</strong>. The more friction you remove, the more blood flow we enable into the pump science ecosystem—capital moves freely, and users are more likely to stick around. pump science relies on continuous participation (trading, data analysis, product purchases), so <strong>Solana’s</strong> lower friction is a critical advantage. Being a first mover in Solana DeSci undoubtedly helped us get to this point, and has been and will continue to be the chain that gives pump science its best chance at success.</p><h1 id="h-7-endgame" class="text-4xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0"><strong>7. Endgame</strong></h1><p>For typical meme coins, the end game is to get listed on a centralized exchange to open liquidity and dump on more traditional traders. We envision a different endgame for tokens on pump science - rather than exit liquidity being more traders, having it be from product sales that bring net new, non-speculative liquidity. This would be transformational, as traditional consumers can purchase longevity products and indirectly support the token markets without even necessarily knowing it.</p><p>The future is clear: AI agents proposing, trading, and prescribing longevity medications that continuously optimize our biological age, while we humans are hanging out on the beach, letting them do the hard work.</p><p>With pump.science, this vision is not so far-fetched. We have the systems in place to enable this, we only need the data throughput to generate sufficient data to activate it. With open, real time data and markets, AI agents can become the power users of pump science. In addition, with product sales contributing directly to the market, the agents should prefer to play a positive expected value game rather than the zero-sum meme coin trading game. Due to the organic demand for longevity supplements and an aging population, this trend should not only hold but strengthen.</p><h1 id="h-conclusion" class="text-4xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0"><strong>Conclusion</strong></h1><p>pump science is about simplifying the DeSci value proposition and being realistic about what has product-market-fit in crypto - speculating. This speculative energy literally is science itself - taking gambles with a low probability of finding a gem. We just have very trad names for this process in biotech - it’s called high throughput screening. By tying high throughput screening to gem hunting in crypto, we can fuel the existing biotech discovery process with a lifeblood of new compounds and research.</p><p>On a more philosophical level:</p><ul><li><p>Markets are a price seeking machine</p></li><li><p>Science is a truth seeking machine</p></li><li><p>Blockchains are a consensus seeking machine</p></li></ul><p>By creating tokenized markets for science we are creating a more optimal technology to publish, price, and generate consensus about knowledge.</p><h2 id="h-about-pumpscience" class="text-3xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0"><strong>About pump.science</strong></h2><p><a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://pump.science/">pump.science</a> is a crypto-powered research protocol for launching and funding scientific experiments, starting with longevity studies. Born in the trenches of DeSci, the protocol enables users to launch compound tokens, fund real scientific experiments through trading fees, and watch research unfold in real-time—from worm studies to human trials. pump.science is making science self-custodial, transparent, and maximally degen. For more information, visit <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://pump.science/">pump.science</a> or follow us on <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://x.com/pumpdotscience">X</a>.</p><h1 id="h-" class="text-4xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0"></h1>]]></content:encoded>
            <author>pump-science@newsletter.paragraph.com (pump.science)</author>
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            <title><![CDATA[RODeo Ride 2: The Battle Continues]]></title>
            <link>https://paragraph.com/@pump-science/rodeo-ride-2-the-battle-continues</link>
            <guid>bYTiy0hKzRQIXmTHI0Ao</guid>
            <pubDate>Mon, 10 Feb 2025 19:14:18 GMT</pubDate>
            <description><![CDATA[In week 2 of our 8-week RODeo mice experiment series, the competition on the rotaod heated up. Nine mice faced off on the rotating rod to test whether Urolithin A (URO) or Rifampicin (RIF) could boost endurance. Would the reigning champions hold their ground, or would a new contender be crowned the big cheese? Let’s dive into the action.Round 2 RoundupThe stage was set for another high-octane test:Nine fearless miceTwo life-extending compounds: Urolithin A (URO) & Rifampicin (RIF)One rotating...]]></description>
            <content:encoded><![CDATA[<p>In week 2 of our 8-week RODeo mice experiment series, the competition on the rotaod heated up. Nine mice faced off on the rotating rod to test whether <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://pump.science/experiments/URO?mint=FvgqHMfL9yn39V79huDPy3YUNDoYJpuLWng2JfmQpump&amp;exp=9ae1e48c-d459-4d1a-9bad-8eb0b2ee6d96">Urolithin A (URO)</a> or <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://pump.science/experiments/RIF?mint=GJtJuWD9qYcCkrwMBmtY1tpapV1sKfB2zUv9Q4aqpump&amp;exp=3792f454-2e0c-4302-bf0c-d586d502e0a5">Rifampicin</a> (RIF) could boost endurance.</p><p>Would the reigning champions hold their ground, or would a new contender be crowned the big cheese? Let’s dive into the action.</p><h2 id="h-round-2-roundup" class="text-3xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0">Round 2 Roundup</h2><p>The stage was set for another high-octane test:</p><ul><li><p>Nine fearless mice</p></li><li><p>Two life-extending compounds: Urolithin A (URO) &amp; Rifampicin (RIF)</p></li><li><p>One rotating rod</p></li><li><p>Better wifi so viewers could see the whole stream (thanks, Elon Mousk)</p></li></ul><h2 id="h-the-crowds-picks" class="text-3xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0">The Crowd’s Picks</h2><p>Before the RODeo began, PhDegens locked in their predictions on <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://hedgehog.markets/?marketType=pump.science">Hedgehog Markets</a>.</p><p>Which mouse would stay on the rod the longest? Let’s see who they picked.</p><figure float="none" data-type="figure" class="img-center" style="max-width: null;"><img src="https://storage.googleapis.com/papyrus_images/69ff8657bd4edb5200186cb68bad11b40841a694e6f062e141d16458fc06b2db.png" alt="Round 2: RODeo prediction markets" blurdataurl="data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACwAAAAAAQABAAACAkQBADs=" nextheight="600" nextwidth="800" class="image-node embed"><figcaption HTMLAttributes="[object Object]" class="">Round 2: RODeo prediction markets</figcaption></figure><p>The community was all in on a repeat performance from Lionel Mousey, with an 89.7% chance of winning. Alex Rodriguez, with his raw talent, came in as the second pick with 4.5% odds of winning.</p><p>So… how did the cheese crumble?</p><h2 id="h-who-ruled-the-rod-week-2-results" class="text-3xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0"><strong>Who Ruled the Rod: Week 2 Results</strong></h2><figure float="none" data-type="figure" class="img-center" style="max-width: null;"><img src="https://storage.googleapis.com/papyrus_images/226bf68da968f1ea88ebebec4b955d32e41a99e6d8b6585afd1ce7f054be341b.jpg" alt="Round 2: Total Rotarod Time (Sum of 3 Trials, Seconds)" blurdataurl="data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACwAAAAAAQABAAACAkQBADs=" nextheight="600" nextwidth="800" class="image-node embed"><figcaption HTMLAttributes="[object Object]" class="">Round 2: Total Rotarod Time (Sum of 3 Trials, Seconds)</figcaption></figure><p>The results delivered a mix of triumphs and surprises:</p><p><strong>Overall Winner:</strong> Lionel Mousey clinched victory once again, extending his reign as the king of the rotarod. He ruled the rod for so long that it actually stopped spinning. This legend clocked the same average time on the rod as week 1, a testament to his consistency. <strong>Top 3 in Total Seconds on the Rod:</strong></p><ol><li><p>Lionel Mousey (URO): 901 seconds</p></li><li><p>Alex Rodentriguez (Control): 882 seconds</p></li><li><p>Mice Jordan (RIF): An impressive leap to 818 seconds, up from 686 seconds in Week 1.</p></li></ol><h3 id="h-compound-insights" class="text-2xl font-header !mt-6 !mb-4 first:!mt-0 first:!mb-0">Compound Insights:</h3><figure float="none" data-type="figure" class="img-center" style="max-width: null;"><img src="https://storage.googleapis.com/papyrus_images/4dacc57fba545be20092c89b8c818a906242e1bc239699ba5a6a9bbf65c18fb9.jpg" alt="Mouse performance by group over time" blurdataurl="data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACwAAAAAAQABAAACAkQBADs=" nextheight="600" nextwidth="800" class="image-node embed"><figcaption HTMLAttributes="[object Object]" class="">Mouse performance by group over time</figcaption></figure><p>The control mice improved by an average of 44.9% — not bad for raw talent.</p><p>The Rifampicin group showed the greatest overall improvement, with a 48.7% boost in performance.</p><ul><li><p>Mousain Bolt showed modest gains.</p></li><li><p>Mice Jordan delivered a dramatic “hockey stick” performance, clearly unlocking a new level in his game.</p></li><li><p>And Lemice Hamilton didn’t look as strong as he did in week 1. Maybe next week, little buddy.</p></li></ul><p>While Lionel Mousey solidified his status as RODeo champ, his performance gains were offset by the notable decline of his teammate Elon Mousk. He (and his performance) continued to fall from a total of 307 seconds in Week 1 on the rod to just 204 seconds in Week 2.</p><h2 id="h-whats-next-save-the-dates-and-stay-in-the-know" class="text-3xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0">What’s Next: Save the Dates &amp; Stay in the Know</h2><p>The RODeo isn’t over yet—this was just Week 2 of our 8-week ride.</p><p>Round 3 is coming in hot. <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://hedgehog.markets/pool/7qZCDDe2NiJefFRy7vYKcRuBoQmhSfiz9j6uvt6yLLRa/">Lock in your predictions</a> now and <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://lu.ma/0ioyg2eo">join us live</a> as our mice go another round on the rod. Plus, some special guests are dropping in — the pump.science Drug Devs— who will share alpha on the next compounds coming to the platform. Don’t miss a future rodeo! Check out the full dates below and <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://lu.ma/pumpscience">subscribe</a> to our calendar to stay updated.</p><p>Miss the last RODeo? Watch the <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://www.youtube.com/live/byIghVidjsg">replay</a>.</p><figure float="none" data-type="figure" class="img-center" style="max-width: null;"><img src="https://storage.googleapis.com/papyrus_images/36fc16decc1eb9916cfe6b22a1c8ee3c4434f7883143bb45fc49b7dc816769e9.png" alt="RODeo dates" blurdataurl="data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACwAAAAAAQABAAACAkQBADs=" nextheight="600" nextwidth="800" class="image-node embed"><figcaption HTMLAttributes="[object Object]" class="">RODeo dates</figcaption></figure><p>There is a lot cooking in the pump.science lab. For the latest on the pump.science experiments, new compound launches, and the RODeo follow our <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://x.com/pumpdotscience">X</a> or join our <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://t.me/pump_science">telegram</a>.</p><h2 id="h-about-pumpscience" class="text-3xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0">About pump.science</h2><p>pump.science is a crypto-powered research protocol for launching and funding scientific experiments, starting with longevity studies. Born in the trenches of DeSci, the protocol enables users to launch compound tokens, fund real scientific experiments through trading fees, and watch research unfold in real-time—from worm studies to human trials. pump.science is making science self-custodial, transparent, and maximally degen. For more information, visit <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://pump.science/">pump.science</a> or follow us on <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://x.com/pumpdotscience">X.</a></p>]]></content:encoded>
            <author>pump-science@newsletter.paragraph.com (pump.science)</author>
            <enclosure url="https://storage.googleapis.com/papyrus_images/aeab7fc76aba4f64089775a13f2417d719b7ba546baa6abf25aed287de6ea081.png" length="0" type="image/png"/>
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            <title><![CDATA[The Results of Our First RODeo]]></title>
            <link>https://paragraph.com/@pump-science/the-results-of-our-first-rodeo</link>
            <guid>7pWK8taFr25JXRQO7kHy</guid>
            <pubDate>Mon, 03 Feb 2025 06:13:36 GMT</pubDate>
            <description><![CDATA[Science is usually slow. Boring. Locked away in labs where only a handful of people get to see what’s happening. Not here. Not at pump.science. Today, we’re excited to share the results from our first RODeo, a live-streamed mouse experiment on the rotarod. This marks a key milestone in our research protocol, which has moved from worms to flies and now mice. For the first time, you got to place your predictions, watch the science happen, and see the results unfold in real-time. Let’s break it ...]]></description>
            <content:encoded><![CDATA[<p>Science is usually slow. Boring. Locked away in labs where only a handful of people get to see what’s happening.</p><p>Not here. Not at pump.science.</p><p>Today, we’re excited to share the results from our first RODeo, a live-streamed mouse experiment on the rotarod. This marks a key milestone in our research protocol, which has moved from worms to flies and now mice.</p><p>For the first time, you got to place your predictions, watch the science happen,  and see the results unfold in real-time.</p><p>Let’s break it down.</p><h2 id="h-rolling-with-the-mice" class="text-3xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0">Rolling with the Mice</h2><p>We’ve already tested Urolithin A and Rifampicin in worms and flies—now it’s time to see how they perform in mice. The Setup?</p><ul><li><p>Nine brave mice.</p></li><li><p>Two life-extending compounds: Urolithin A (URO) &amp; Rifampicin (RIF).</p></li><li><p>A rotating rod designed to test endurance, strength, and balance.</p></li><li><p>live-streamed in real-time, so the community could watch the action unfold.</p></li></ul><p>To make things even micier, we partnered with Hedgehog Markets, letting the community predict the winner.</p><p>Would the PhDegen crowd make the right call? Or were they about to get played by an underdog?</p><p>Or should we say... undermice.</p><h2 id="h-the-predictions-who-did-the-community-pick" class="text-3xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0">The Predictions: Who Did the Community Pick?</h2><figure float="none" data-type="figure" class="img-center" style="max-width: null;"><img src="https://storage.googleapis.com/papyrus_images/f649d0bf4970722d7c1a239511f872f84040ba967296842a94ce7285dfcd04c5.png" alt="Predictions for First RODeo on Hedgehog Markets" blurdataurl="data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACwAAAAAAQABAAACAkQBADs=" nextheight="600" nextwidth="800" class="image-node embed"><figcaption HTMLAttributes="[object Object]" class="">Predictions for First RODeo on Hedgehog Markets</figcaption></figure><p>Through our collaboration with <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://hedgehog.markets/?marketType=pump.science">Hedgehog Markets</a>,  our PhDegen community put their money where their mouse is —predicting which mouse would stay on the rod the longest.</p><h3 id="h-community-favorites" class="text-2xl font-header !mt-6 !mb-4 first:!mt-0 first:!mb-0">Community Favorites:</h3><ol><li><p>Lionel Mousey – The undisputed favorite, leading the market with $385 in bets and a 30.6% implied chance of victory.</p></li><li><p>Alex Rodentriguez – A strong contender, backed by several high-confidence wagers.</p></li><li><p>Mousain Bolt &amp; Lemice Hamilton – Solid odds, expected to put up a fight.</p></li></ol><p>And then there was Lance Hairstrong—the longshot with just $17 in bets (1.3% implied chance)—a true underdog.</p><p>So… did the market get it right?</p><h2 id="h-what-went-down-the-rodeo-results" class="text-3xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0"><strong>What Went Down: The RODeo Results</strong></h2><p>Some mice dominated. Others? Not so much.</p><h3 id="h-top-performers" class="text-2xl font-header !mt-6 !mb-4 first:!mt-0 first:!mb-0">Top Performers:</h3><figure float="none" data-type="figure" class="img-center" style="max-width: null;"><img src="https://storage.googleapis.com/papyrus_images/10ff3ff02d8725cf78f7a2ba30018dccd4641a3684088bc09ebacc9c5b52570c.png" alt="Total Time on Rotatod in Seconds by Mouse" blurdataurl="data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACwAAAAAAQABAAACAkQBADs=" nextheight="600" nextwidth="800" class="image-node embed"><figcaption HTMLAttributes="[object Object]" class="">Total Time on Rotatod in Seconds by Mouse</figcaption></figure><ol><li><p>Lionel Mousey- Lived up to the hype, staying on the rod for 901 seconds. Absolute machine.</p></li><li><p>Alex Rodentriguez - Kept it close with 824 seconds. Strong. Consistent. A true endurance athlete.</p></li><li><p>Lemice Hamilton - Solid 725 seconds before tapping out.</p></li></ol><h3 id="h-compound-insights" class="text-2xl font-header !mt-6 !mb-4 first:!mt-0 first:!mb-0">Compound Insights:</h3><figure float="none" data-type="figure" class="img-center" style="max-width: null;"><img src="https://storage.googleapis.com/papyrus_images/f1bb626f2424bda6d2492643747965e50b4ead9cb5669012ec54da946cf290de.png" alt="Mouse Performance Over Time" blurdataurl="data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACwAAAAAAQABAAACAkQBADs=" nextheight="600" nextwidth="800" class="image-node embed"><figcaption HTMLAttributes="[object Object]" class="">Mouse Performance Over Time</figcaption></figure><ul><li><p>Mice were dosed for four days leading up to the event.</p></li><li><p>Too soon to tell if the compounds are having an effect but RIF is looking better than URO in the firs trial.</p></li></ul><p>This is just one test—but these early results are already making us rethink which interventions actually improve endurance.</p><h3 id="h-the-rodeo-by-the-numbers" class="text-2xl font-header !mt-6 !mb-4 first:!mt-0 first:!mb-0">The RODeo by the Numbers</h3><ul><li><p><strong>Participants:</strong> Over 2,700+ live viewers on X and YouTube</p></li><li><p><strong>Predictions:</strong> $1,256 in community predictions placed on Hedgehog Markets</p></li></ul><p>Whether you backed a champion or got rugged by a mouse, you were part of the first-ever live-streamed longevity experiment with prediction markets.</p><h2 id="h-why-this-matters" class="text-3xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0">Why This Matters</h2><p>Most research happens behind closed doors. We’re changing that.</p><p>By making science live, interactive, and gamified, we’re not just running experiments—we’re creating a system where anyone can engage and participate in the next scientific breakthrough.</p><p>The best research shouldn’t be hidden. It should be a game that everyone can play.</p><h2 id="h-whats-on-the-horizon-for-pumpscience" class="text-3xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0">What’s On the Horizon for pump.science?</h2><p>This was just Week 1 of our 8-week RODeo series.</p><ul><li><p>More RODeo trials – We’re tracking these mice over multiple weeks to see if the effects hold.</p></li><li><p>New compounds – Expanding into new worm studies with VitaDAO.</p></li><li><p>Human trials – Pulse wearable experiments are on the horizon.</p></li></ul><p>Don’t miss our next RODeo. <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://lu.ma/bod1ruyc">Register now</a> to watch live and make your predictions for round 2 <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://hedgehog.markets/pool/szxy4QGWNV5inRHf9xADJ9p5kWqYNXEjQfgdhJkWWek/">here</a>.</p><h3 id="h-big-thanks-to-our-mvps-the-mice" class="text-2xl font-header !mt-6 !mb-4 first:!mt-0 first:!mb-0">Big Thanks to Our MVPs: The Mice</h3><p>Shoutout to our little furry champions—they’re pushing the boundaries of what we know about endurance, aging, and performance.</p><p>Missed the live event? Watch the <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://youtube.com/live/hgEjbOQASeU">replay</a></p><p>Check out the full RODeo results on<a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://pump.science/"> pump.science</a></p><p>We’re not just funding science. We’re playing it.</p><p>See you at the next RODeo.</p><h2 id="h-about-pumpscience" class="text-3xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0">About pump.science</h2><p>pump.science is a crypto-powered research protocol for launching and funding scientific experiments, starting with longevity studies. Born in the trenches of DeSci, the protocol enables users to launch compound tokens, fund real scientific experiments through trading fees, and watch research unfold in real-time—from worm studies to human trials. pump.science is making science self-custodial, transparent, and maximally degen**.** For more information, visit <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://pump.science/">pump.science</a> or follow us on <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://x.com/pumpdotscience">X</a>.</p>]]></content:encoded>
            <author>pump-science@newsletter.paragraph.com (pump.science)</author>
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            <title><![CDATA[pump.science and Hedgehog Markets Launch Prediction Markets for Live Mouse Studies — A New Way to Engage with Science]]></title>
            <link>https://paragraph.com/@pump-science/pump-science-and-hedgehog-markets-launch-prediction-markets-for-live-mouse-studies-a-new-way-to-engage-with-science</link>
            <guid>D4k0yEtLD2r9vK5I7ze0</guid>
            <pubDate>Wed, 08 Jan 2025 15:03:32 GMT</pubDate>
            <description><![CDATA[Neuhausen am Rheinfall, Switzerland – Ready to put your scientific knowledge to the test? In a first-of-its-kind collaboration, pump.science and Hedgehog Markets are bringing prediction markets to live longevity experiments, offering a whole new way for communities to engage with cutting-edge research. This isn’t about luck—it&apos;s about using scientific knowledge and data to actively participate in the future of longevity research. Centered around pump.science’s RODeo, a series of weekly l...]]></description>
            <content:encoded><![CDATA[<p><em>Neuhausen am Rheinfall, Switzerland</em> – Ready to put your scientific knowledge to the test? In a first-of-its-kind collaboration, <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://www.pump.science/">pump.science</a> and <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://hedgehog.markets/">Hedgehog Markets</a> are bringing prediction markets to live longevity experiments, offering a whole new way for communities to engage with cutting-edge research. This isn’t about luck—it&apos;s about using scientific knowledge and data to actively participate in the future of longevity research.</p><p>Centered around pump.science’s <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://mirror.xyz/0xbe44A79FBF6f42455559C8b6D1cBBa109BaF3F10/kMaIt0vt6E2AC-wijnYd59DGfsvd8PGollQZ5ETsImQ">RODeo</a>, a series of weekly live-streamed longevity experiments using the rotarod device (an industry-standard tool for measuring mouse endurance and motor function), each week, mice are treated with potential life-extending compounds, and undergo endurance testing. Participants can access video footage of the individual mice, preliminary data, and insights from past experiments to inform their predictions on which mouse will stay on the rotarod the longest.</p><p>RODeo prediction markets will open before each experiment and close prior to the start of the study, giving participants time to analyze available data from fly studies, individual mouse preview data, and any recently completed RODeo studies. By studying this information, participants can make skill-based predictions based on the scientific insights available to them—similar to how professionals analyze weather, economic, or election data to make informed predictions.</p><p>&quot;RODeo is a leap forward for how people can support and interact with scientific research,&quot; said <strong>Benji Leibowitz, founder of pump.science.</strong> &quot;By streaming real-time mouse endurance tests with prediction markets, we&apos;re ushering in a new and more engaging participation model of scientific discovery.&quot;</p><p><strong>Kyle DiPeppe from Hedgehog Markets</strong> added, &quot;Prediction markets have proven powerful for everything from sports to politics. Now, we’re bringing that same power to science, where participants can use their knowledge to predict the outcomes of live experiments and actively engage in the research process.”</p><p>RODeo builds on pump.science’s successful research progression from worm to fly studies, taking its exploration of longevity compounds to new animal models and engagement formats.  Each week, participants will have new data to analyze, building a growing body of knowledge to inform their predictions on Hedgehog Markets.RODeo prediction markets will open in the coming days at <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://hedgehog.markets/science/">hedgehog.markets/science</a>. For more details on the experiments, follow pump.science on <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://x.com/pumpdotscience/">X</a>. For information on prediction markets, visit <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://hedgehog.markets/">Hedgehog Markets.</a></p><p>RODeo will be streamed live on the pump.science platform, with real-time data from the experiments available for participants to follow after markets close. Full details on how to access the live streams and markets will be available soon.</p><h3 id="h-about-pumpscience" class="text-2xl font-header !mt-6 !mb-4 first:!mt-0 first:!mb-0"><strong>About pump.science:</strong></h3><p>pump.science is a crypto-powered research protocol for launching and funding scientific experiments, starting with longevity studies. Built by Molecule and backed by the Solana Foundation, the platform lets citizen scientists follow live longevity experiments. For more information, visit <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://www.pump.science/">pump.science</a> or follow us on <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://twitter.com/pumpdotscience">X</a>.</p><h3 id="h-about-hedgehog-markets" class="text-2xl font-header !mt-6 !mb-4 first:!mt-0 first:!mb-0"><strong>About Hedgehog Markets</strong></h3><p>Hedgehog Markets is a permissionless prediction market that serves as a powerful tool for truth discovery. By enabling users to participate in prediction markets, Hedgehog allows the alignment of financial incentives leading to more accurate forecasts. This protocol not only monetizes information asymmetry but also encourages deeper research and analysis, as participants are motivated to uncover the truth. Ultimately, Hedgehog Markets harnesses collective intelligence to refine predictions, providing a more accurate reflection of future outcomes based on real financial commitment. For more information, follow us on <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="http://x.com/hedgehogmarket">X</a> or check out<a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="http://hedgehog.markets/"> hedgehog.markets</a> for available markets.</p><p>Pump.science Media Contact: <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="mailto:pumpdotscience@molecule.to">pumpdotscience@molecule.to</a></p><p>Hedgehog Contact: <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="mailto:hello@hedgehog.markets">hello@hedgehog.markets</a></p>]]></content:encoded>
            <author>pump-science@newsletter.paragraph.com (pump.science)</author>
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            <title><![CDATA[RODeo: Everything You Need to Know
]]></title>
            <link>https://paragraph.com/@pump-science/rodeo-everything-you-need-to-know</link>
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            <pubDate>Wed, 08 Jan 2025 15:01:40 GMT</pubDate>
            <description><![CDATA[From worms to flies, the compounds being tested on pump.science have shown promising results. Now we enter the next phase: mouse trials. Welcome to the RODeo.Why RODeo?Our mice will undergo endurance testing on a rotating rod — the rotaROD — the industry standard for measuring motor function and vitality in aging research. Hence, RODeo. Each week, mice receiving interventions or placebo, will face off to see which compound enhances performance more.The ExperimentGroups of mice:Control group: ...]]></description>
            <content:encoded><![CDATA[<p>From worms to flies, the compounds being tested on pump.science have shown promising results. Now we enter the next phase: mouse trials.</p><p>Welcome to the RODeo.</p><h2 id="h-why-rodeo" class="text-3xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0">Why RODeo?</h2><p>Our mice will undergo endurance testing on a rotating rod — the rotaROD — the industry standard for measuring motor function and vitality in aging research. Hence, RODeo.</p><p>Each week, mice receiving interventions or placebo, will face off to see which compound enhances performance more.</p><h2 id="h-the-experiment" class="text-3xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0">The Experiment</h2><h3 id="h-groups-of-mice" class="text-2xl font-header !mt-6 !mb-4 first:!mt-0 first:!mb-0">Groups of mice:</h3><ul><li><p>Control group: 3 mice</p></li><li><p>Compound group(s): 3 mice per compound tested</p></li></ul><h3 id="h-how-it-works" class="text-2xl font-header !mt-6 !mb-4 first:!mt-0 first:!mb-0">How It Works:</h3><p>Each week, mice face a series of endurance trials on the rotarod — a rotating cylinder designed to test their athletic performance.</p><p><strong>The challenge:</strong> stay on the rotating rod as long as possible. The rod begins rotating slowly, and speeds up over time. Staying on the rod will test their athletic endurance.</p><h2 id="h-the-study-protocol" class="text-3xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0">The Study Protocol:</h2><p>Before official trials begin, mice undergo pre-training at a steady 4rpm to get comfortable with the rotarod.</p><h3 id="h-weekly-testing-structure" class="text-2xl font-header !mt-6 !mb-4 first:!mt-0 first:!mb-0">Weekly Testing Structure:</h3><ul><li><p>Mice are placed on the rotarod in specified lanes.</p></li><li><p>Each mouse completes 3 trials in one day.</p></li><li><p>Maximum of 15-minute recovery between trials.</p></li><li><p>Speed increases gradually until all mice have fallen off.</p></li><li><p>Time, until they fall off (latency), is recorded.</p><ul><li><p>This data can be analyzed to assess motor coordination and balance.</p></li></ul></li></ul><h3 id="h-trial-details" class="text-2xl font-header !mt-6 !mb-4 first:!mt-0 first:!mb-0">Trial Details:</h3><ul><li><p>Maximum trial length: 5 minutes</p></li><li><p>Testing continues for 8 weeks</p></li></ul><h3 id="h-data-collection" class="text-2xl font-header !mt-6 !mb-4 first:!mt-0 first:!mb-0">Data collection:</h3><p>Time on the rod (latency) measures motor coordination and balance. For reliability:</p><ul><li><p>All trials happen on the same day.</p></li><li><p>Results averaged across three attempts per mouse.</p></li><li><p>Performance tracked weekly.</p></li><li><p>Data verified within 24 hours</p></li></ul><h3 id="h-how-to-watch" class="text-2xl font-header !mt-6 !mb-4 first:!mt-0 first:!mb-0">How to Watch:</h3><p>Catch the RODeo live on the pump.science:</p><ul><li><p>Twitch</p></li><li><p>YouTube</p></li><li><p>Twitter</p></li></ul><p>Stream links are shared before the events so users know where to watch the science.</p><h2 id="h-how-to-participate-in-the-rodeo" class="text-3xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0">How to Participate in the RODeo:</h2><p>The RODeo offers multiple ways to engage with the science:</p><ol><li><p><strong>Watch Live Science in Action</strong></p><p>Enjoy real-time streams of the experiments, from warm-ups to trials.</p></li><li><p><strong>Trade Compound Tokens</strong></p><p>Speculate on outcomes by trading compound tokens throughout the duration of the RODeo.</p></li></ol><p><strong>Skill-Based Predictions</strong> <em>(Powered by Hedgehog Markets)</em></p><p>Participate in prediction markets, which open ~7 days before the experiment and close just before it starts.</p><p><strong>Data and Insights Available to RODeo Participants:</strong></p><ul><li><p>A complete list of mouse names.</p></li><li><p>Data from fly studies.</p></li><li><p>Preliminary mouse data powered by Mouse Tracker.</p></li><li><p>Live video feed of mice in the warm-up area.</p></li><li><p>Previously completed RODeo trials.</p></li></ul><h2 id="h-prediction-market-details" class="text-3xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0">Prediction Market Details</h2><h3 id="h-market" class="text-2xl font-header !mt-6 !mb-4 first:!mt-0 first:!mb-0">Market:</h3><p>Which mouse will stay on the rotarod the longest across all three trials?</p><h3 id="h-market-timeline" class="text-2xl font-header !mt-6 !mb-4 first:!mt-0 first:!mb-0">Market Timeline:</h3><ul><li><p><strong>Markets Open</strong>: ~7 days before the trial starts.</p></li><li><p><strong>Markets Close:</strong> 30 minutes before the first trial event begins.</p></li><li><p><strong>Results Posted</strong>: Within 24 hours (via pump.science).</p></li></ul><h3 id="h-how-to-participate-in-prediction-markets" class="text-2xl font-header !mt-6 !mb-4 first:!mt-0 first:!mb-0">How to Participate in Prediction Markets?</h3><ul><li><p><strong>Connect &amp; Browse</strong></p><ul><li><p>Visit <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://hedgehog.markets/science">hedgehog.markets/science</a></p></li><li><p>Connect your Solana wallet (Phantom, Backpack, or Solflare)</p></li><li><p>Browse available markets (click arrow to expand details)</p></li></ul></li><li><p><strong>Place Your Predictions</strong></p><ul><li><p>Choose your prediction</p></li><li><p>Enter your USDC amount</p></li><li><p>View potential payout (Note: Payouts can change based on other participants&apos; predictions)</p></li></ul></li><li><p><strong>Market Resolution</strong></p><ul><li><p>Results verified within 12-24 hours</p></li><li><p>Once resolved, button becomes &quot;Claim&quot;</p></li><li><p>Check the &quot;Positions&quot; tab for live predictions and available claims</p></li></ul></li></ul><p><strong>Important:</strong></p><ul><li><p>Cannot exit markets early</p></li><li><p>All predictions are locked until market resolution</p></li><li><p>USDC returned directly to your wallet after claiming</p></li></ul><h2 id="h-key-dates" class="text-3xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0">Key Dates:</h2><ul><li><p>Prediction Market Opens: Jan 27th</p></li><li><p>First RODeo event: January 31st</p></li><li><p>Subsequent Markets: open 7 days before each event</p></li><li><p>Results posted: Within 24 hours</p></li><li><p>Claims begin after verification</p></li></ul><h2 id="h-faqs" class="text-3xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0">FAQs:</h2><ol><li><p><strong>What is the rotarod?</strong> A rotating cylinder used to measure motor coordination and balance in research.</p></li><li><p><strong>Can I watch without participating?</strong> Absolutely! Live streams are open to everyone. How are winners determined in prediction markets? Results are based on official data verified and posted on pump.science.</p></li><li><p><strong>How is the data from the experiments verified?</strong> All data is reviewed and verified by our research team, Tracked Bio, within 24 hours of the trials, ensuring accuracy and reliability before results are posted.</p></li><li><p><strong>Will I have access to historical data from previous RODeo events?</strong> Yes, summaries and data from past RODeo events will be available for reference and analysis.</p></li><li><p><strong>What happens if technical issues affect the live stream or trials?</strong> In the event of technical difficulties, all efforts will be made to resume as quickly as possible. Any significant disruptions will be communicated via our official channels. All the experiments will be recorded. If we cannot resume the stream, the full recordings of the experiments will be made available.</p></li><li><p><strong>How are mouse names chosen?</strong> Mouse names are selected through a community voting process, details of which will be shared before the trials begin.</p></li><li><p><strong>What happens if a mouse doesn’t complete all three trials?</strong> Since the main endpoint in rotarod is latency, latency will be recorded as 0 seconds for each trial where the mouse cannot walk at all on the beam when the session starts.</p></li><li><p><strong>What is the Mouse Tracker data? How is this different than the data from the rotarod?</strong> Tracked Bio&apos;s TrackedMouseWatcher(TM) data is in-cage of analysis of the mice in their &quot;home&quot; environment. Therefore, we can observe the activity of the mice in an uninterrupted fashion, which overall is a more unbiased data capture. Data that will be generated for this experiment will be distance and speed of the mice. Other features may potentially be included as well.</p></li><li><p><strong>How do these endpoints correlate to longevity outcomes in the mice?</strong> Rotarod is a well-recognized and validated endpoint that assesses motor coordination, balance, and overall neuromotor performance in mice, critical health indicators and functional ability as organisms age. Please see an example study by going to <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="http://www.pubmed.gov">www.pubmed.gov</a> and searching the PMID: 26822304.</p></li><li><p><strong>How can you ensure the right data is correlated to the right mouse?</strong> Each mouse will maintain the same lane in the rotarod, so identity will be preserved.</p></li><li><p><strong>How is the experiment designed to ensure the mice are not being harmed? Is the experiment reviewed and approved by an ethics committee?</strong> This study was approved by the IACUC. The Institutional Animal Care and Use Committee (IACUC) is a federally mandated committee in the United States responsible for overseeing and approving research involving animals, including mice, to ensure humane and ethical treatment in compliance with federal regulations.</p></li></ol><h2 id="h-about-pumpscience" class="text-3xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0">About pump.science:</h2><p>pump.science is a crypto-powered research protocol for launching and funding scientific experiments, starting with longevity studies. Built by Molecule and backed by the Solana Foundation, the platform lets citizen scientists follow live longevity experiments. For more information, visit <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://www.pump.science/">pump.science</a> or follow us on <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://twitter.com/pumpdotscience">X</a>.</p>]]></content:encoded>
            <author>pump-science@newsletter.paragraph.com (pump.science)</author>
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            <title><![CDATA[The Next Arena: Pump.Science + Pulse]]></title>
            <link>https://paragraph.com/@pump-science/the-next-arena-pump-science-pulse</link>
            <guid>TnfNgIYCct57uW3A6r7e</guid>
            <pubDate>Thu, 12 Dec 2024 15:02:35 GMT</pubDate>
            <description><![CDATA[The science happening in our arena isn&apos;t just entertainment. Every worm, fly, and soon mouse experiment has been building toward something bigger — something human. The vision was always to create products that enhance human health, backed by sound evidence for life extension. To make this leap from animal to human studies, we needed a partner who had the right tool to measure whether the compounds work in humans. For human studies, we needed Pulse; a solana enabled wearable deviceSay He...]]></description>
            <content:encoded><![CDATA[<p>The science happening in our arena isn&apos;t just entertainment. Every worm, fly, and soon mouse experiment has been building toward something bigger — something human.</p><p>The vision was always to create products that enhance human health, backed by sound evidence for life extension. To make this leap from animal to human studies, we needed a partner who had the right tool to measure whether the compounds work in humans.</p><p>For human studies, we needed Pulse; a solana enabled wearable device</p><h2 id="h-say-hello-to-pulse" class="text-3xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0"><strong>Say Hello to Pulse</strong></h2><p>The <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://www.pulse.site/store">Pulse</a> wearable measures heart rate, HRV, and VO₂ max – the best predictor of how long you&apos;ll live. But here&apos;s the real kicker: you own your data, you earn when it&apos;s used.</p><figure float="none" data-type="figure" class="img-center" style="max-width: null;"><img src="https://storage.googleapis.com/papyrus_images/e46a8e2d741006fcdbad72fbc115ec3a3a4fcc6a0428f2a3dc96ed63f3b580b8.jpg" alt="Pulse wearable device that will be used in the pump.science human studies" blurdataurl="data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACwAAAAAAQABAAACAkQBADs=" nextheight="600" nextwidth="800" class="image-node embed"><figcaption HTMLAttributes="[object Object]" class="">Pulse wearable device that will be used in the pump.science human studies</figcaption></figure><h2 id="h-making-history-first-on-chain-wearable-study" class="text-3xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0"><strong>Making History: First On-Chain Wearable Study</strong></h2><p>We&apos;re launching something that&apos;s never been done: several hundred participants, one supplement, and health data streaming straight to the <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="http://pump.science/">pump.science</a> platform. No more waiting months for results hidden behind closed doors – this is science unfolding live for all to see.</p><p>It&apos;s simple: participants take a daily supplement (or placebo) while wearing their Pulse device. Their anonymized health data streams directly to the pump.science platform throughout the study. No complicated protocols, no waiting for results – just real-time data streaming to the platform.</p><h3 id="h-the-study-what-you-need-to-know" class="text-2xl font-header !mt-6 !mb-4 first:!mt-0 first:!mb-0">The Study: What You Need to Know</h3><ul><li><p>Duration: starting Q2 2025, exact duration TBD</p></li><li><p>Participants: several hundred adults, open to ages 18-80</p></li><li><p>Location: Open globally</p></li><li><p>Requirements: Participants must own a Pulse device</p></li><li><p>Commitment: Daily supplement (or placebo) intake + wearing Pulse device</p></li><li><p>Data Collection: Continuous monitoring of heart rate, HRV, VO₂ max, and other key metrics</p></li><li><p>Privacy: You control your data - opt in/out at any time, data on pump.science is anonymized.</p></li><li><p>Reward: As a reward for participating, users will receive a 3 months supply of the first supplement tested.</p></li></ul><h3 id="h-ways-to-get-involved" class="text-2xl font-header !mt-6 !mb-4 first:!mt-0 first:!mb-0">Ways to Get Involved</h3><p>Want to participate in the study and get ahead of the game?</p><p>While we don&apos;t provide the devices, you can get your Pulse device through our <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://www.pulse.site/store?r=science">link</a> and receive an exclusive pump science community discount. The discount is automatically applied at checkout.</p><p>If you want to participate in the human study, get on the <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://moleculeprotocol.typeform.com/to/jSk2NYzy?utm_source=blog&amp;utm_medium=blog&amp;utm_campaign=pulse">list</a> for future updates. You don&apos;t need to be a token holder to participate – we&apos;re recruiting from both the Pulse biohacker community and our pump.science community.</p><p>Not participating? You can still:</p><ul><li><p>Trade tokens based on study outcomes</p></li><li><p>Follow the data as it unfolds</p></li></ul><p>To stay up to date on the human studies, follow the pump.science <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://x.com/pumpdotscience">X</a> and <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://t.me/pump_science">telegram</a> or the Pulse <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://x.com/PulseNoLimits">X</a>.</p><h2 id="h-more-than-just-research" class="text-3xl font-header !mt-8 !mb-4 first:!mt-0 first:!mb-0"><strong>More Than Just Research</strong></h2><p>This was never just about watching animals live longer. It&apos;s about pushing human potential:</p><ul><li><p>Pump.science brings the compound</p></li><li><p>Pulse tracks the life gains</p></li></ul><p>Ready to make history? The arena opens soon.</p><p><strong>About Pump.Science</strong></p><p>Pump.Science is a crypto-powered research protocol for launching and funding scientific experiments, starting with longevity studies. Built by Molecule and backed by the Solana Foundation, the platform lets citizen scientists follow live longevity experiments, trade tokens based on outcomes, and hold rights to potentially life-extending compounds. For more information, visit <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://www.pump.science/">pump.science</a> or follow us on <a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://twitter.com/pumpdotscience">X</a>.</p><p><strong>About Pulse</strong></p><p>Pulse is changing the future of healthcare with digital twin technology that balances privacy, personalization, and prevention. By putting individuals in control of their health data, Pulse brings real value to users and drives medical innovation through its open health network. For more information, visit<a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="http://pulse.site"> pulse.site</a> or follow us on<a target="_blank" rel="noopener noreferrer nofollow ugc" class="dont-break-out" href="https://twitter.com/pulsenolimits"> Twitter</a>.</p>]]></content:encoded>
            <author>pump-science@newsletter.paragraph.com (pump.science)</author>
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