Yesterday morning, as the largest logistics base in the South City, the 480,000 square metres of logistics base in the village of white basin kilns in the Toyota district began demolition work for nearly half a year. In the future, in addition to the full elimination of the low-end industry, this will be upgraded to a 3000 acres of the garden and a green ecological office space of 200,000 square metres.

At 9 a.m., with machine rumours, a warehouse at the White Basin Logistic Centre was vacated and another side worker began to shun off the roof. It is understood that the stock-taking and closure of businesses was completed last year and that demolitions will continue in the first half of this year. According to the relevant head of the village, the village of White basin kiln is located between four and five rings in the south, and the adjacent village science and technology parks are parked in a long-standing and well-known city, which has historically been known for the production of white pimps.

As urbanization progresses, the village of White Basin kiln is gradually being developed as a collective economic organization at the village level with logistics, real estate and flowers as subjects of economic growth, including the Beijing Building Materials Supply Station, the White Basin Logistic Centre, the Beijing Sun-yielding Trade Limited and the Beijing-based White basin kilnol centre.

“The development and expansion of recent years have brought together a large number of external populations in the village, and so many problems have emerged, such as security concerns. As the functioning of the non-capital has moved forward, the dismantling process will also be completed in the first half of this year, when the village of White basin kilns has been completely shut down and removed from the lower ends of the market, logistics and so on.” The Officer-in-Charge of the Caspian Region indicated that 80 per cent of these 480,000 square metres of land will be planned to be built as a flower cultural batching park, greening bencheons with white-basin kilns, pharmacies, monthly seasons, and upgrading 200,000 square metres of land to open green office space, developing green eco-industries, high-end services and innovative entrepreneurship industries.

In the future, the environment in and around the villages will be greatly improved while eradicating the concentration of mobile populations and reducing security concerns. “The use of land for stipulation can be greened by 3,000 acres, with cities left behind and industrial parks increased”. The Officer-in-Charge indicated that the village of White basin kilns would also be based on scientific planning and the use of dismantled land for sound industrial development, providing basic security for the economic development and quality of life of the village. (Source: Beijing Youth Report)

It is understood that in order to prepare this love breakfast, the couple of fried dough sticks have been busy since the late night of January 5. “Noodles have to be reconciled the night before and can only be used the next morning. Soybeans have to be soaked in advance.” Wife Wang Limei said.

On the morning of January 6, the reporter visited the “fried dough sticks husband and wife”, and only the eldest sister was grinding soybean milk at home. “Your eldest brother went out to publicize in the community early in the morning. I just called him and came back to fry fruit later.” Wang Limei said: “our fruit has no vanadium. It is made with traditional baking powder and baking soda. We have to let everyone eat healthily.”

After a while, her husband Li Ming came home and the couple cooperated skillfully. When the reporter asked how long the epidemic was sent last year and how much money he paid for it, the answer surprised the reporter. “Last year, the epidemic was sent for more than two months. Unexpectedly, the epidemic lasted so long and took more than 20000. In order to change our taste, we made steamed stuffed buns once a week. At that time, the pork was more than 30 yuan a kilogram.” More than 20000 yuan. What kind of concept is it for a couple who still feel very expensive because they need to pay 800 yuan a month to rent a house and have been worried about not having enough money to open a small breakfast shop. “Both of our parents are very supportive and remit money when we have no money… Our biggest wish now is to pass the epidemic quickly and let the people quickly return to normal life.” Li Ming said.

In the early morning, although the temperature in Shencheng was cold, the couple looked happy. In order to reach the detection point of No. 1 school in workers’ village as soon as possible, the reporter felt the cold wind blowing on his face and didn’t feel cold anymore.

Obesity, type 2 diabetes and dyslipidemia are recognized risk factors for NAFLD. In addition, conditions that cause dysregulation of liver methionine metabolism, such as rapid weight loss, hunger and malnutrition, may also lead to NAFLD.

Recently, researchers from the University of Hong Kong published in the Journal theranostics entitled “hepatic PRMT1 ameliorites die induced hepatic stearosis via induction of PGC1” α” The results show that PRMT1 / HNF-4 is activated α/ pGC-1 α Signaling pathway is a potential therapeutic strategy against nonalcoholic fatty liver disease in obese people.

Image source: https://pubmed.ncbi.nlm.nih.gov/35401831/

Over nutrition leads to overexpression of PRMT1, but hypomethylation of protein is observed in the liver of obese people. The dynamic changes of PRMT1 expression and methyltransferase activity in the progression of fatty liver disease remain elusive.

In this study, the researchers used the recombinant adeno-associated virus mediated gene delivery system to regulate the expression level of PRMT1 in the liver of diet induced obese mice, so as to explore the role of PRMT1 in liver steatosis. The researchers further used a group of obese people with biopsy confirmed nonalcoholic fatty liver disease to support the observation in mouse models.

The researchers demonstrated that the knockout of PRMT1 gene promoted the occurrence of hepatic steatosis in high-fat diet (HFD) mice. Overexpression of wild-type PRMT1, rather than methyltransferase deficient mutant prmt1g80r, can reduce diet induced hepatic steatosis. This observation is conservative in a sample of obese people with biopsy confirmed nonalcoholic fatty liver disease.

In terms of mechanism, the methyltransferase activity of PRMT1 α- four α Raised to PGC-1 α To induce PGC-1 α To reduce hepatic steatosis induced by HFD by enhancing pgc-1-mediated fatty acid oxidation.

Liver PRMT1 induces PGC1 α Improve feed induced hepatic steatosis

Image source: https://pubmed.ncbi.nlm.nih.gov/35401831/

To sum up, the researchers passed HNF-4 α And PGC-1 α The mechanism dependent induction of hepatic fatty acid oxidation reveals the protective effect of PRMT1 on hepatic steatosis in obese subjects. The findings of this study help explain why methyl donor supplementation prevented the progression of NAFLD in obese subjects. PRMT1 inhibitors are being developed to treat various cancers, so it is necessary to evaluate the potential side effects of PRMT1 inhibitor treatment on liver lipid metabolism and liver injury.

reference:

Lu Xu et al. Hepatic PRMT1 ameliorates diet-induced hepatic steatosis via induction of PGC1 α. Theranostics. 2022 Feb 28; 12(6):2502-2518. doi: 10.7150/thno. sixty-three thousand eight hundred and twenty-four

“The fourth shot of the new coronavirus vaccine?” Recently, after the announcement of the news that Henan will carry out the sequential enhanced immunization of the COVID-19 vaccine, many citizens questioned that the sequential enhanced immunization means the fourth injection? Just had a booster injection. Do you still need it? How to choose? On February 21, the elephant news reporter interviewed Zhang Mingyu, deputy chief physician of the Institute of immunization planning of Henan CDC.

Not the fourth

On February 19, after the announcement of the news that Henan will carry out the sequential enhanced immunization of the COVID-19 vaccine, many citizens asked, does the sequential enhanced immunization mean the fourth injection?

“Not the fourth.” Zhangmingyu, deputy chief physician of the Institute of immunization planning of Henan CDC, answered that, in short, sequential immunization is only one more way to strengthen the injection of COVID-19, not the fourth injection.

What is homologous immunity?

It is understood that the previous enhanced vaccination of COVID-19 vaccine in China implemented homologous enhancement, that is, the vaccine with the same route as the previous one needs to be selected when enhancing needle selection.

What is sequential immunization?

Another choice and name of reinforcing needle.

Sequential booster immunization is heterologous vaccination, that is, vaccination that can choose other production routes.

At present, there are three production routes of COVID-19 vaccine in China: inactivated vaccine, adenovirus vector vaccine and recombinant protein vaccine. For people who have been vaccinated with the third booster needle, there is no need to vaccinate again.

For some people who need booster injections, there is an additional choice, either homologous booster or sequential booster immunization.

Who can play sequential immunization? Those who have been vaccinated by these three manufacturers can choose sequential vaccination

It is understood that there are three conditions for the objects eligible for sequential immunization: the first is the people over 18 years old, and the second is to complete two doses of inactivated vaccine according to the procedure. The vaccine is one of the three novel coronavirus inactivated vaccines of Sinopharm Zhongsheng Beijing Co., Ltd., Beijing Kexing Co., Ltd. and Sinopharm Zhongsheng Wuhan Co., Ltd. Third, there was no booster immunization, that is, the third injection was not given.

Originally called for “unification”, now called for “mixed fighting”?

Many people wondered why they had previously recommended homologous vaccination along the same technical route, but now they have suggested “mixed fighting” from different sources? In this regard, Shao Yiming, a member of the expert group of vaccine research and development of the scientific research group of the joint prevention and control mechanism of the State Council, said that according to the previous experience of infectious disease prevention and control, a single vaccine can deal with conventional viruses, but for cunning viruses that are good at mutation, different vaccines can be “combined”.

What are the advantages of sequential immunization?

Shao Yiming explained: first, different vaccines can complement each other. Second, side effects can be reduced for some people. Because different people have different constitutions, some people may have more serious side effects on a certain vaccine, and the occurrence of side effects can be reduced through vaccine transformation.

After the third booster injection, do you still need sequential immunization?

unwanted.

Can homologous and sequential booster immunization be carried out at the same time?

Select one of them.

And you must be at least 18 years old and have completed the whole vaccination for more than 6 months before you can choose the booster needle.

“Post-90s” Huang Jiajie is a girl from Xiangshui Town, Baoting Li and Miao Autonomous County. She once worked on a cruise ship in Southeast Asia for many years. In 2019, she returned to her hometown and was employed as the general manager assistant of jabulun xiangshuigu shared farm, ending her wandering life.

“Post-70s” Chen long is a retired soldier in Xiangshui Town, Baoting. He has worked in the mainland for many years. In 2019, he returned to his hometown and was hired as the foreign relations contact of jabulun xiangshuigu shared farm, ending his wandering life.

“In the past, our place was a poor mountain valley. People in the village couldn’t see hope and ran outside.” Huang Jiajie said that after the construction of jabulun water valley shared farm, farmers in mountainous areas were driven to get rich together in many ways, and everyone came back one after another.

“Men of our age, old and young, should have suitable jobs in their hometown. Of course, if they want to come back and work outside, it’s no better than staying at home.” Chen Long said that after coming back, although the current income is not too high, but the sense of happiness is much stronger.

“Yabulun · shared water valley shared farm, which pioneered the ‘three Communists’ development and operation mode of’ common ownership, sharing and common wealth ‘, is an innovative measure for Hainan to implement the strategy of Rural Revitalization and building a beautiful countryside, and will explore a replicable and popularized road for the integrated development of rural primary, secondary and tertiary industries in the whole province and even the whole country.” Xiao Yong, general manager of Hainan yabulun Investment Co., Ltd., said that since the implementation of the project, the sharing development mode of multi-party linkage has been used to lease or take shares in idle resources such as agricultural land and idle housing. Enterprises have driven villagers to become rich by providing villagers with housing, minimum guarantee, floating dividends and labor remuneration.

Xiao Yong said that relying on landscape resources, the shared farm project of enjoying water valley will develop the health care tourism industry, create a large framework of “Pan tourism industry”, take the health care farm as the core product, fully activate the multiple values of ecological and agricultural resources, and build a solid industrial foundation for the revitalization of rural areas in mountainous areas.

The game began at 1 p.m. after guessing, Ke Jie took charge of the black against Liao Yuanhe. Previously, Ke Jie had won six consecutive games against Liao Yuanhe. In the prelude stage, the two sides took the lead in the battle on the right side of the chessboard. The black chess battle was unfavorable and suffered heavy losses. Since then, white chess has steadily grasped its advantages and dealt with it concisely everywhere. Black chess failed to find a good opportunity to turn the table, and Ke Jie finally admitted the negative. In this way, Ke Jie, who ranked first in the domestic ranking, stopped in the top 32 of the rotten Ke cup, while Liao Yuanhe finally ended his six consecutive defeats against Ke Jie.

On the other hand, Ding Hao, who ranks second in the domestic grade, is in charge of the black game against Li Xuanhao, who played in the Asian Cup qualifier a few days ago. Li Xuanhao had a brilliant performance in the Asian Cup qualifier, while Ding Hao was in a stunningly low state, ending his Asian Cup qualifier with 8-1. Today, Ding Hao’s fog breaking situation has not yet come. In the prelude stage, both sides chose the complex change of MI Dao. The white chess was handled skillfully, and the black chess did not lose. However, since then, the black chess was eager to win and attacked rashly. Instead, it gave the white chess a chance and made itself passive. Finally, Li Xuanhao defeated Ding Hao again and won the game.

Mi Yuting, who was also defeated in the selection of the Asian games like Ding Hao, also failed to win the match against Vietnam in wartime today. Mi Yuting is very good at straight-line calculation and violent attack and kill. Shi Yue was once known as “one-stop game”, and finally won in today’s struggle. In another game of chess, Gu Zihao also lost in the attack and kill, losing to quick knife Li Qincheng. So far, Ke Jie, Ding Hao, Gu Zihao and Mi Yuting, the top four in the domestic ranking, have all stopped in the top 32.

It is worth mentioning that Quzhou said this year that the national rotten coca cup will be upgraded to an annual world competition, and the champion of this rotten coca cup will directly escort the top 32 of the rotten coca World Cup. Thus, the weight of the current rotten coca cup champion can be seen.

The second round will continue tomorrow. Please pay attention!

Today’s results and tomorrow’s match are as follows:

Audience experience AI voice recognition, which can automatically change the sound according to the reading content

The staff demonstrated the process of virtual script game

From April 23 to 25, the first three-day national reading conference was held in Beijing. “Digital reading” has become a focus topic of the conference. According to the 2021 China digital reading report released by China audio visual and Digital Publishing Association, the number of digital reading users in China in 2021 was 506 million, an increase rate of 2.43% compared with 494 million in 2020; The per capita reading volume is 11.58 electronic reading and 7.08 audio reading.

According to Zhang Yijun, the first vice president of China audio visual and Digital Publishing Association, this annual report is compiled based on the survey data of 46 digital reading platforms (enterprises), traditional publishing units, research institutions and nearly 100000 digital reading users in China. The data collection time span is from January to December 2021.

In 2021, the overall revenue scale of digital reading in China was 41.57 billion yuan. Among them, public reading was 30.25 billion yuan, audio reading was 8.55 billion yuan and professional reading was 2.77 billion yuan.

In terms of revenue structure, subscription revenue was 21.907 billion yuan, advertising revenue was 10.683 billion yuan, copyright revenue was 6.568 billion yuan and other revenue was 2.412 billion yuan. Compared with 2020, subscription revenue, advertising revenue and copyright revenue increased by 1.270 billion yuan, 3.337 billion yuan and 2.383 billion yuan respectively, and their contribution rates to the growth of the whole market scale reached 18.17%, 47.73% and 34.10% respectively.

The report also shows that by the end of 2021, the number of digital reading works on the shelves was about 34.4686 million, an increase of 11.06% compared with 31.036 million in 2020. Among them, there are about 32.0462 million online literary works, about 1.8054 million e-books and about 617000 other works.

In 2021, the number of digital reading users in China was 506 million, an increase rate of 2.43% compared with 494 million in 2020; Per capita reading volume: 11.58 electronic reading and 7.08 audio reading; In terms of reading duration, e-reading users have entered the stage of deep reading, while audio reading presents the characteristics of fragmentation.

Zhang Yijun said that from the data of the above report, China’s digital reading industry still maintained a good development momentum in 2021, with the continuous expansion of market scale, the continuous emergence of high-quality works, the continuous rise of user stickiness, remarkable achievements in overseas expansion and the continuous enhancement of guarantee ability.

scene

Digital reading achievement exhibition

Bring immersive reading experience

The digital reading achievement exhibition is on display in the digital reading experience Hall of the first national reading conference. Maze · Ruyi Linlang atlas, Xinhua Dictionary app, Chinese poetry class, Guoyun inheritance app, “history and learning” multimedia publishing project, shadow China ar picture book, “track online” AR, CNPC reading app system, Migu 5g cloud party construction, 5g cloud travel Museum, “kaishu storytelling” doll, tomato novel AI reading, etc. provide an immersive reading experience for the audience.

“Not far from the southwest of the bell and Drum Tower is the famous Shichahai. The so-called ‘sea’ is actually a shallow lake, half of which is planted with lotus and half is turned into rice fields…” the reporter of Beijing Youth Daily clicked on the concept of tomato novel on the scene, and the timbre was fresh. Listening to the electronic screen, a highly anthropomorphic voice of Liu Xinwu’s “bell and Drum Tower” delivered by Tianjin crosstalk made people really experience the taste of humor.

According to the on-site staff, the AI reading of tomato novel is provided with technical support by the volcanic voice team. In order to make the AI voice close to the effect of real-life broadcasting, the model has been explored and optimized in multiple directions such as synthetic sound quality, rhythmic stress, tone and intonation, providing users with a highly anthropomorphic immersive listening experience.

Moreover, the AI reading of tomato novel also creates a multi style timbre matrix, which can adapt to the different settings of the characters in the novel, express a variety of emotions such as happiness and sadness, and let the timbre of AI properly show the joys, sorrows and joys in the story. In particular, the option of listening to the concept timbre, which can perform different roles through multi role dialogue and multi style timbre, can intelligently predict emotion and tone, and make listening more immersive. In the characteristic dialect, the northeast dialect, old fellow’s voice and Tianjin’s voice are the three dialects, which make the listening more interesting.

“I’m old sun Lai, I’m the monkey king of Huaguo Mountain…” at the booth of “Uncle Kai telling stories”, the reporter saw a set of story dolls of four Tang monks, teachers and disciples learning from the West. Pick up the vivid shape of the monkey king, press the button, and you will hear one paragraph after another of the story of Qi Tian Da Sheng.

According to the staff, physical products are derived based on online virtual audio, which creatively combines the doll image loved by children with the high-quality content of Uncle Kay to create an industry-leading product form - story doll. It does not need to rely on the Internet, which is convenient for children to use at any time and independently in different scenes, provides children with excellent use experience, and reduces children’s dependence on parents’ mobile phones for listening to stories.

activity

46 bookstores nationwide

“The most beautiful bookstore of the year”

On the morning of April 24, the first national reading conference · the most beautiful bookstore of the year was held in Beijing. A total of 46 bookstores across the country won the honor of “the most beautiful bookstore of the year”. Among them, there are two bookstores in Beijing, namely Beijing Book Building and PAGEONE Beijing square store.

It is understood that the 46 bookstores that won the “most beautiful bookstore of the year” this time cover 31 provinces (autonomous regions and cities) and Xinjiang production and Construction Corps. Among them, there are not only state-owned Bookstore brands such as Xinhua, but also private Bookstore brands; There are not only comprehensive large bookstores, but also small and fine characteristic bookstores; There are not only the old brands of bookstores that have been transformed and upgraded, but also the new faces of bookstores that have emerged in recent years.

They have distinctive features and prominent highlights, showing the beauty of red inheritance, cultural conservation, responsibility, business innovation, integrated development and environmental design of physical bookstores, reflecting the latest achievements of innovative development of physical bookstores in recent years and the spirit of fearing difficulties and making progress in adversity.

Xicheng District “reading spring”

system

Since January 20, the district governments (management committees) have organized public security, emergency, market supervision, transportation, urban management and other departments to jointly carry out special inspection and rectification actions on fireworks and firecrackers, focusing on key parts such as wreath shops, flower gift shops, wedding etiquette, funeral service companies, small commodity markets, market fairs, tomb areas, villages in the city, suburban joints and other key areas, Carry out unified inventory action, and timely investigate and deal with illegal operation and storage of fireworks and firecrackers.

▲ fireworks and firecrackers seized by Donghu police in the store

On the morning of January 25, the public security branch of the East Lake ecotourism scenic spot found illegal storage of firecrackers in a grocery store in Xiajia village. The police immediately investigated and dealt with it, and collected 6 bundles of firecrackers and 10 boxes of fireworks. The police immediately brought back the shop owner Kang for review. After investigation, Kang admitted the illegal fact of illegal storage and operation of fireworks and firecrackers, and the police detained him for 3 days according to law.

▲ the shopkeeper Kang was administratively detained

At about 20:00 on January 26, when the public security brigade of Jiang’an District public security branch and the police of chenjiaji police station inspected a cheap supermarket in chenjiaji, the scene seized 8 boxes of fireworks being sold to the outside world, and the police summoned the shopkeeper Leng to the public security organ. After investigation, Leng was sentenced to administrative detention for 2 days.

▲ fireworks seized by Jiangan police

It is understood that during the Spring Festival, the city will pay close attention to key periods, parts and checkpoints, strengthen inspection, control and investigation, and form a high-pressure situation. Taking the police station as the unit, the public security organ organized social forces to establish a whip ban publicity and law enforcement team to carry out whip ban publicity, blocking, control and law enforcement. Public security checkpoints set up checkpoints at the main road crossings into the city to investigate and deal with the illegal carrying of fireworks and firecrackers in a timely manner. At the same time, all districts and departments widely carry out whip ban publicity through various channels such as news media, outdoor advertising, LED screens of commercial stores, subway broadcasting and mobile phone text messages.

Police reminder

It is strictly prohibited to purchase, transport, carry, store and set off fireworks and firecrackers in violation of regulations. During the Spring Festival, the city’s publicity and law enforcement forces are on the road every day to carry out whip ban publicity, dissuasion and law enforcement, and call on the general public to consciously abide by the whip ban. The police encourage citizens to actively call 110 and other police reporting phones to report violations.

Source: public security detachment

Correspondent Wang Wei, Chen Long

The upgrade content of chrome 99 is not much. In terms of functionality, it mainly moves the download button from the bottom to the top of the toolbar, and there will be better prompts. When downloading something, it is blue and turns into a gray button after downloading.

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