The state of entrepreneurship was informed that in May 2023, Nanjing Yukio Takasu Biosciences Ltd. (hereinafter referred to as “Rede clouds”) announced the completion of nearly 100 million yuan renminbi B+ swaps, co-sponsored by the Dutch ponds, the Qana Bank of Thailand, the Ingkin and Ttato Foundation, and the ongoing holding of the current shareholder Chariba investment. Kai is capitalized as the sole financial adviser for the current round. The fund will simultaneously develop a new generation of EGFR inhibitors H002 in China and the United States for clinical trials in non-small cell pulmonary cancers, while accelerating the development of pipelines and technology based on a unique structural pharmacological platform based on mangroves.

Mangune is a clinical phase of small molecular innovation research and development, with structural pharmacology at its core, integrating molecular power simulations, calculating chemical and artificial intelligent (AI) cutting-edge techniques. Mang cloud organisms have accumulated unique structural biology data and algorithmic models in several areas of clinical demand-oriented junctions, and have established several small molecular opiniotic drug research and development pipelines that cover tumours, rare diseases and other treatment areas with highly unmet clinical needs. Currently, H002, a company-owned, entirely new molecular drug, is conducting a clinical test study in Central America and is expected to be the best option for the next generation of EGFR-TKI inhibitors. At the same time, the company’s first inclination project for multiple tumours, such as breast cancer, has entered the PCC phase and is expected to declare clinical in 2024.

With regard to this round of financing, Dr. H.E. Dr. CEO 廖 has said that in the past year, infrared cloud organisms have grown from an early R&D company with a leading innovation concept in an industry to an innovative R&D business in a clinical phase with a global vision, and we are very grateful for the sustained recognition and firm support of investors and our experts and cooperation agencies in clinical pilot projects. Mang cloud organisms will continue to attract talent from industry, focus on patients and clinical needs, integrate new technology tools, develop the best innovative recipe for drugs based on the dynamic structure of protein, and actively promote clinical development and cooperation with a global vision.

The Managing Director of the Dutch ponds Club expressed his great pleasure in participating in the financing of the mangrove of mangroves. Mang clouds have an efficient implementation team that combines scientific research with industrial background. The company’s use of structural pharmacology as a core technology, based on a composite structure of proven candidates and drums, is based on a combination of calculating methods to understand the dynamic structure of drugs and drums and to optimize the design of drugs, which is a cutting-edge technology area. The new generation of EGFR inhibitor research and development data developed by companies on this technical platform is well known and encouraging, and we look forward to a safer and effective solution for the urgent need for clinically three generations of EGFR inhibitors for more patients.

The President of the Gulf of Guinea Board, Yang, indicated that the red cloud bios have a leading new pharmacological-based pharmacological design platform, and that the structure and functioning of the vinyl prote and its abrupt transformers at a atomic resolution level are well informed by articulating, molecular simulating and calculating chemistry-enabled cantons, and we look very well at the future development of mangroves with artificial intelligent, molecular simulating and chemistry optimization techniques.

The In-kind Investment Implementation Partner, Inc., stated that H002 could not only address the problem of drug-resistant patients, but also have a large market for the treatment of new generations of EGFR inhibitors that had previously been encountered at the time of research and development at this point.

The Thai Air Messengers Foundation partnered in saying that the red cloud organisms are our first bunker biomedical project, and we look very well at the team and technical platform of mangroves, especially the H002 products, which have been the result of multi-year research by the infrared cloud teams and show a clear disincentive in the tests of cells and animal models for a variety of single mutations, bitumals and three-craters. The results of the pre-clinical experiment also show good bioavailability and organizational distribution and drug treatment windows of H002, and clinical preliminary data show good pharmacological efficacy and safety in H002 and look forward to more product data disclosure.

Charles Barba’s Capital Partner stated that we continue to look at the technological platforms and innovative pipelines of mangroves, especially the clinical data of H002, which are more encouraging, and that this is a full demonstration of the growing maturity of the technology platform for red clouds, team-to-points and clinical transformations, and our confidence in the future development of companies.

Dr. Liu Daqun, a capital partner, said that it was a great honour to assist in the completion of the current round of financing for mangroves. The winterization of pharmaceutical biocapitalization since last year, which included financing of $200 million completed by Ventus Therapeutics, and the introduction of TYK2 inhibitors in the payment of $4 billion to Nimbus Therapeutics from the field, have shown that drug development based on structural pharmacology is a high point for small molecular innovation. And infrared cloud organisms, based on a wealth of “trust experience”, include structural pharmacology, protein dynamic simulations, ultra-higher fluctuation screening and entirely new AI technology platforms, as well as the resulting drug molecules, suggest that companies are also at the global forefront in this area. Thank you very much for the confidence of the Red cloud biological team in Kai, and we hope that the red clouds will accelerate progress in the development line for early benefit.

For more information on the project, please visit the “Veterinary Analysis”.

In the evening of 14 days of the new waves of entertainment, the chewing of the chef is a social platform for the son’s paedophilia, who is exposed to the face of the children and who have given birth to the children. A number of friends of the network questioned the consent of the former wife, S., in response to a communication from the broker, said that everything had been referred to a lawyer.

Snowfalls

The ski was “invaded” in your veil:

While winter is cold, it is only this winter that we can look forward to snow flowers. In the instantaneous dancing of snow flowers, you have dragged and remembered the waves of the past, at which time the photographer takes a glass at random, and the veil of marriage is naturally only common.

Separation in snow

The snow flow symbolizes the purity of love, and the veil of marriage is embarrassed by the “invasion” of the snow flow. And, of course, when you coincide with the ski flow of the sky, the sky flower also brings a sense of dynamism to your veil of marriage.

Diving in snow

The overall colour of the veil of marriage is simple, but the effect of the belt is unusual.

Background, uniqueness

Natural snowstorms, pitfalls

There is no snow-flapping, but there is a background of natural snowstorms, such as a veil of marriage. When mountain trees, house roads are covered by the snow flowers of white flowers, you stayed on the hillside. Ibid.

Xiao Cui’s job search story

Xiao Cui said that when he paid the highest attention to employment, he graduated and looked for a job in 2011. “At that time, smart phones were not fully popularized, and there was no big data to push recruitment information. I went to the website of the school employment guidance center to download recruitment notices one by one, and then printed them one by one. Or I watched the recruitment sea newspaper posted by employers in the school and the crowded scene around the posters. I still have a deep memory.”

Xiao Cui remembers that at that time, the teacher frowned and said “this year’s employment situation is very severe”. The number of college graduates in 2011 was 6.6 million. Ten years later, according to the Ministry of education, the number of college graduates in 2022 is expected to reach 10.76 million, with a record scale and increment. If the employment situation is “severe” when there are more than 6 million graduates, we can imagine the situation this year.

At the same time, the Ministry of education also pointed out that we should fully recognize the difficulties and challenges we face. For example, the ability of some small and medium-sized enterprises to expand employment has declined, and the epidemic has an adverse impact on campus recruitment activities. On the one hand, the number of employees has reached a new high, and on the other hand, there is still uncertainty in the employment demand of the employment market, which is equivalent to “lifting one hand up and pressing the other hand down”. However, the employment demand and employment demand are just needed, not dough. There is no way to stretch the two hands and become longer and disappear as soon as they are pinched. No one can do without work, no one can do without work. As stated in this year’s government work report, we should “vigorously broaden employment channels” and “strengthen employment and entrepreneurship policy support and continuous online services”.

Look at the change: add “employment” to the name of the employment guidance website

Back ten years ago, in the Employment Guidance Center website of Xiaocui school at that time, the “recruitment notice” with a large number of downloads would be pushed to the home page, all of which were large central enterprises, state-owned enterprises and public institutions.

“At that time, there was no saying of ‘big internet factory’. If you want to find some recruitment notices for small and micro enterprises or private enterprises, you will find them faster by using reverse order.”

Xiao Cui said that when you click on this website today, its name has changed from “Employment Guidance Center” to “employment and entrepreneurship guidance center”, adding a lot of content about students’ independent entrepreneurship policies and successful cases; Secondly, a hundred flowers bloom in the recruitment of units, including not only central enterprises, state-owned enterprises and well-known Internet enterprises, but also a large number of start-ups and small, medium and micro enterprises. It reflects the improvement of the country’s economic vitality in recent years, and great changes have taken place in the format of many industries.

“For students majoring in media, the cultural and creative industry is now very developed. Not only large media groups and institutions can choose, but also various media companies, animation companies and visual art companies are blooming everywhere.”

College student employment representative committee to support recruitment

While the state provides us with new career choices, we also need to have a new positioning for ourselves, that is, the concept of career choice.

Wu Duanhua, deputy to the National People’s Congress, suggested: we should do a good job in the publicity and guidance of college graduates’ employment, establish a correct outlook on job selection, form reasonable work and income expectations, find our own positioning and realize our life ideal.

When graduates are willing to change their concept of job selection, adhere to reality and have the courage to go to the front line and difficult places at the grass-roots level, it must be a broad world for them and will make great achievements.

Shi Daning, member of the CPPCC National Committee, believes that college graduates should be guided and encouraged to work at the grass-roots level, which can not only transport talents for the grass-roots level, but also an important way to broaden the employment channels of college graduates.

The students must have learned an important knowledge point in the political class, that is, the strategy of Rural Revitalization. At the national level, it has been clearly proposed to cultivate and support industries in poverty-stricken areas for a long time, which requires a large number of talents. From the perspective of employment, it is to create a stage for college graduates to show their strength.

Wang Mengmeng, deputy to the National People’s Congress and Secretary of the general Party branch of Jiuzi village, Dingyuan County, Anhui Province, became a “college student village official” eight years ago. Now she has grown from a “student baby” in the mouth of the villagers to an expert in developing characteristic planting. She said that in Jiuzi village, there are five graduates out of 10 village cadres, who have become a new force for Rural Revitalization.

Where else can employment channels be broadened? Li Xiaoli, deputy to the National People’s Congress, reminded that small, medium-sized and micro enterprises, known as the “capillaries” of the economy, can absorb a large number of jobs, and even college students have support policies for starting their own businesses. She also called on the society to pay more attention to college students who choose flexible employment and give more social tolerance and recognition.

In addition to the direction of these employment and entrepreneurship officers mentioned by the above deputies and members of the two sessions of the National People’s Congress, Liu Hong, deputy to the National People’s Congress, also proposed that the country has now raised the active response to population aging to the height of national strategy and should promote the coordinated development of aging undertakings and industries.

Zheng Gongcheng, deputy to the National People’s Congress, also suggested that now the “three child policy” is coming, in addition to food and clothing, the service industry, the real estate industry, and infant related teaching and auxiliary institutions will be affected. This belongs to “post grabbing people”, instead of “people grabbing posts”, which also solves the practical problems of parents.

In order to make college graduates get a good job, on the one hand, the students’ Outlook on job selection should be changed and their scenery should be long-term; On the other hand, policies and assistance measures also need to be continuously online and updated.

With the continuous development of society, new so-called “blue ocean” industries are bound to emerge. The graduates with knowledge, vision and aggressiveness aim at the market and find the right position, and their life will be brilliant in the end!

This paper is selected from physics, issue 2, 2022

The original deep field photos taken by the Hubble Space Telescope are one of the most iconic images in astronomy. This image consists of a staggering number of distant galaxies embedded in a black background. It was obtained after Hubble made a series of observations on a small area of the constellation Ursa Major in December 1995. Inspired by this classic photo, astronomers began planning a new mission to study the early universe - a mission to see the earlier universe and the earliest galaxies that existed 300 million years after the big bang. But to do this, we need the largest telescope ever, a telescope much larger than Hubble’s 2.4-m mirror. The answer is: the next generation space telescope (NGST), which is a huge space telescope with a 6.5m splicing main mirror, is expected to realize a series of new discoveries.

Inspired by the potential of NGST, American astronomers soon selected it as the top priority of space-based missions in the “ten-year survey report” in 2000 - a wish list for future projects compiled by the National Academy of Sciences, the Academy of engineering and the Academy of medicine. The telescope is scheduled to launch in 2007 at a cost of $1 billion. In 2002, it was renamed James Webb Space Telescope (JWST) after the former director of NASA. However, the dreams of using the new telescope to study the evolution of galaxies and how stars and planets formed quickly became nightmares. The budget of the project rose sharply, so that the US House of Representatives proposed to cancel it completely in 2011, but the troubled project was saved at the last minute with the joint rescue of scientists, the public and the media. Just in 2018, when the cost of the project was about to exceed the $8 billion mark, the US Congress had to vote to provide it with more funds.

JWST now costs an estimated $9.7 billion, and part of the reason behind the surge in costs is the construction of a huge telescope. JWST’s spliced primary mirror, with a diameter of 6.5 m, will be the largest primary mirror ever sent into space (Figure 1). “When we started, we knew we could build a much smaller telescope more safely,” said Nobel laureate cosmologist John Mather, who has led the project at NASA’s Goddard Space Flight Center since the mid-1990s The problem, however, is that smaller telescopes cannot achieve the transformative science astronomers want.

Figure 1 ready for launch. An artist’s impression of the James Webb Space Telescope

However, telescope size is not the only demanding requirement. The light emitted by these early galaxies was elongated by the expansion of the universe. To observe them, astronomers need a telescope that can detect near-infrared and mid infrared wavelengths. To do this, the telescope needs to be placed away from the earth’s thermal radiation, near Lagrange L2, which is behind the sun and the earth. “The other thing is that to achieve the infrared sensitivity we need, the telescope must be very cold,” mather said. “Soon we face a lot of difficult technical challenges.”

Twenty years of hard development have passed, and JWST is finally ready. For most people in astronomy, telescopes will take some time to start working. The launch of the telescope is scheduled for December 24, 2021. However, even if the payload carrying Ariane 5 rocket was launched from the European Space Port in French Guiana, scientists cannot breathe a collective sigh of relief. Although launch is usually the most dangerous part of a space mission, this is not the case for JWST.

This is NASA’s latest and most expensive space eye. Launch will be the simplest part of it. The next thing will determine the success of this mission. This is because before it can push science and space technology to the limit it can achieve, it must first overcome the dangerous deep space unpacking: the 6.5-m-wide main mirror must be carefully and correctly unfolded, and the sun visor the size of a tennis court must be unfolded smoothly. The entire deployment takes about 30 days to complete - if any of the more than 300 things that could go wrong really goes wrong, the telescope’s ability will be limited. In the worst case, the entire telescope will be destroyed, which could set the field back decades. If it succeeds, it will change the research of Astronomy - all thanks to several technological miracles that make JWST a unique and powerful telescope. The sun visor and mirror of the telescope have been successfully deployed and are now in the calibration stage

Symmetrical mirror

During the construction of JWST, one of the biggest challenges faced by engineers is the 6.5m main mirror. Building a mirror of this size is not a problem in itself, but it is a problem to install it into the Ariana 5 rocket only 4.57 m wide without being too heavy to launch into space. The task of solving this particular problem falls to Lee Feinberg, manager of telescope optical components. “The design of the main mirror is very elegant,” Feinberg said, explaining that the essence of this design is that the mirror is foldable: it consists of 18 hexagonal parts, with three small mirrors on each side forming foldable “wings”.

JWST also has a secondary mirror with a diameter of 0.74 m and a smaller tertiary mirror to eliminate the astigmatism of the telescope and flatten the focal plane, so as to prepare for the use of scientific instruments. These three mirrors are made up together

However, through the phone call with the head teacher, she learned that her son’s emotional outburst was not only due to the quarrel, but also directly related to her long-time busy safeguarding rights in the community.

The owners of Ms. you’s community and the industry committee have great differences on various issues in the community, which has affected the daily life of the owners. The owners said that the water had been stopped for more than ten days in January.

At about 1 p.m. on February 17, Ms. you saw the news in the owner group. A neighbor said she saw the child go home and asked her to hurry back. Ms. you’s uneasy heart was finally relieved. However, when they face each other at home, some of the emotional estrangement that has been caused is still obviously between them.

After chatting for a while, Xiaojun was asked about the place where he spent the night last night. His voice suddenly broke out and angrily said that he had been blowing all night on the roof. If a passing college student hadn’t accompanied him for more than three hours and enlightened him, he might not come back now.

Ms. you keeps calling

There was a quarrel over playing with his mobile phone, and his son left home all night

At about 11 a.m. on February 17, the reporter of Xiaoxiang Morning Post contacted Ms. you, who said she was near the gate of Changsha Medical College. The reporter came to the door of the medical school and saw a woman in a white long down jacket. The other party turned around, and the interwoven depression and urgency on her face basically showed her identity.

As soon as you open your mouth, Ms. you couldn’t help choking: “My son usually likes to come here to play and play basketball. I can’t get in. Now I can only ask my friends to help me find him. I really don’t know where to find him. We’ve asked him all the hotels and Internet cafes nearby. His head teacher called this morning and said he didn’t go to school. I thought I would help him deliver his schoolbag if he went to school.”

Time goes back to last night. As usual, Ms. you is busy with the protection of rights in the community. Because many owners are only at home at night, her time to deal with relevant affairs is naturally extended to the evening.

While she was worried about safeguarding her rights, she saw her son playing with his old mobile phone after he came home from school. She was so angry that she didn’t understand how a student who had been in grade three could not put his studies at ease?

After the two glared at each other, their son Xiaojun ran out of the house. Until late at night, Xiaojun hasn’t come back. Ms. you has searched around the big market for many times, but her son has never been found. She waited on her sofa all night and couldn’t sleep. Knowing that her son didn’t bring the key, she specially left the door.

At 8:00 on the 17th, she received a call from her head teacher saying that Xiaojun didn’t go to school. The news of looking for people spread among teachers, students and students’ parents, and many owners also helped to find and inquire about businesses around the market. Ms. you also called the police, but the monitoring of the big market was mostly abandoned due to no management. Only a nearby monitoring showed that Xiaojun ran out of a gate of the big market at 9:34 pm last night.

By 12 noon on the 17th, there was still no news about Xiaojun. Some people worry that Ms. you is very active in safeguarding her rights in the community. Will her son’s “loss of contact” be related to this? Ms. you shed tears and was extremely anxious. What she worried most was that her son would be unhappy.

△ the monitoring showed that Xiaojun ran out of the gate of the big market on the evening of February 16

The son once confided to the head teacher that he often had no water to take a bath and only had cold food when he came home

The phone call made by the head teacher not only let Ms. you know that Xiaojun didn’t go to school, but also let her understand many of the feelings that Xiaojun didn’t tell her.

“The teacher just told me that every time he (Xiaojun) wanted to take a bath, the water couldn’t be opened.” The water supply in the community is often cut off, and according to Ms. you, Xiaojun is a clean person. Because of the lack of water, he can only run to his uncle’s house every three or five times.

The instability of the water source from this market is related to the differences between the owners and the industry committee. According to Ms. you and many owners, the market originally had properties, but after leaving at the end of 2015, it was taken over by the industry committee. Owners said that the industry committee was not established by everyone’s election, “most owners did not vote.”

For several years in a row, the differences between them have become larger and larger, and have reached the level of tit for tat. Ms. you and other owners believed that the industry authority did not act and meddled recklessly, and refused to renew the property fee. The feedback they received from the industry committee was to stop the owner’s water if they did not pay the property fee.

“I want to be really low. I just hope I can pay online and use water like people in other communities. I stopped water for more than ten days in January. During my birthday, my wish on my birthday is to have water every day.” An owner told reporters. The reporter noticed when passing through the community that dozens of barrels of garbage were stacked untreated.

Ms. you is one of the early owners in the market. She has led other owners to protect their rights since last year. When talking about these things, Ms. you will become very angry, and she knows and cares about the development of many things and the experience of some owners. It is obvious that safeguarding rights has basically taken up her energy and attention.

“I told his father that if he is really uncomfortable living here, we can move out and rent a house when he comes back.” Ms. you, who is anxiously looking forward to her son, cried.

In the words of the head teacher, she found that she ignored her son.

“Sometimes I have to go to the owner at night, so I cook four dishes and give them to him. Let him come back and heat them in the microwave.” But for a student who is studying in the third year of junior high school, many students around him may have their parents to accompany him every day. When he comes back, he only has cold meals and empty houses.

△ Ms. you and other owners are searching in the street

My son blew a cold wind on the roof of the building all night, and the college students talked with him until early morning

At about 1:00 p.m., someone sent a message to the owner that Xiaojun had died