Perry and Hamilton, originally in a band together called the Jam Band, met up with Tyler, Kramer, and guitarist Ray Tabano, and formed Aerosmith; in 1971, Tabano was replaced by Whitford. They released a string of multi-platinum albums starting with their eponymous debut in 1973, followed by Get Your Wings in 1974.[14] The band broke into the mainstream with Toys in the Attic (1975) and Rocks (1976).[15] Draw the Line and Night in the Ruts followed in 1977 and 1979. Throughout the 1970s, the band toured extensively and charted a dozen Hot 100 singles, including their first Top 40 hit "Sweet Emotion" and the Top 10 hits "Dream On" and "Walk This Way". By the end of the decade, they were among the most popular hard rock bands in the world and developed a following of fans, often referred to as the "Blue Army".[16] Drug addiction and internal conflict led to the departures of Perry and Whitford in 1979 and 1981.[4] The band did not fare well and the album Rock in a Hard Place (1982) failed to match previous successes.

Perry and Whitford returned to Aerosmith in 1984. After a comeback tour, they recorded Done with Mirrors (1985), which did not meet commercial expectations. It was not until a 1986 collaboration with rap group Run–D.M.C. on a remake of "Walk This Way", and the 1987 multi-platinum release, Permanent Vacation, that they regained their previous level of popularity.[17] In the late 1980s and 1990s, the band won numerous awards for music from the multi-platinum albums Pump (1989), Get a Grip (1993), and Nine Lives (1997), while they embarked on their most extensive concert tours to date. Their biggest hits during this period included "Dude (Looks Like a Lady)", "Angel", "Rag Doll", "Love in an Elevator", "Janie's Got a Gun", "What it Takes", "Livin' on the Edge", "Cryin'", and "Crazy". The band also filmed popular music videos and made notable appearances in television, film, and video games. In 1998, they achieved their first number-one hit with "I Don't Want to Miss a Thing" from Armageddon's soundtrack and the following year, their roller coaster attraction opened at Walt Disney World. Their comeback has been described as one of the most remarkable and spectacular in rock history.[3][4] Additional albums Just Push Play (which included the hit "Jaded"), Honkin' on Bobo (a collection of blues covers), and Music from Another Dimension! followed in 2001, 2004, and 2012. In 2008, they released Guitar Hero: Aerosmith, which is considered to be the best-selling band-centric video game. After five decades, the band continues to tour and record music. From 2019–2022, the band had a concert residency in Las Vegas, which was interrupted from 2020–2021 due to the COVID-19 pandemic.

Aerosmith is the best-selling American hard rock band of all time, having sold more than 150 million records worldwide, including over 85 million records in the United States.[18][19] With 25 gold, 18 platinum, and 12 multi-platinum albums, they hold the record for the most total certifications by an American group and are tied for the most multi-platinum albums by an American group. They have achieved twenty-one Top 40 hits on the US Hot 100, nine number-one Mainstream Rock hits, four Grammy Awards, six American Music Awards, and ten MTV Video Music Awards. They were inducted into the Rock and Roll Hall of Fame in 2001, and were ranked number 57 and 30, respectively, on Rolling Stone's and VH1's lists of the 100 Greatest Artists of All Time.[20] In 2013, Tyler and Perry were inducted into the Songwriters Hall of Fame, and in 2020, the band received the MusiCares Person of the Year award.

Red Hot Chili Peppers were formed in Los Angeles by Kiedis, Flea, guitarist Hillel Slovak and drummer Jack Irons. Due to commitments to other bands, Slovak and Irons did not play on the band's 1984 self-titled debut album, which instead featured guitarist Jack Sherman and drummer Cliff Martinez. Slovak rejoined for their second album, Freaky Styley (1985), and Irons for their third, The Uplift Mofo Party Plan (1987). Irons left after Slovak died of a drug overdose in June 1988.

With new recruits Frusciante and Smith, Red Hot Chili Peppers recorded Mother's Milk (1989) and their first major commercial success, Blood Sugar Sex Magik (1991). Frusciante was uncomfortable with their newfound popularity and left abruptly on tour in 1992. After a series of temporary guitarists, he was replaced by Dave Navarro, who appeared on the group's sixth album, One Hot Minute (1995). Although successful, the album failed to match the critical or popular acclaim of Blood Sugar Sex Magik. Frusciante and Kiedis struggled with drug addiction throughout the 1990s.

In 1998, following Navarro's departure, Frusciante rejoined the band. Their seventh album, Californication (1999), became their biggest commercial success, with 16 million copies sold worldwide. By the Way (2002) and Stadium Arcadium (2006) were also successful; Stadium Arcadium was their first album to reach number one on the Billboard 200 chart. Frusciante left again in 2009 to focus on his solo career; he was replaced by Josh Klinghoffer, who appeared on I'm with You (2011) and The Getaway (2016), before Frusciante rejoined in 2019. They released their 12th and 13th albums, Unlimited Love and Return of the Dream Canteen, in 2022