I had a friend this week inquire about my experience with using TB-500 and BPC-157 in treating knee pain and whether I thought it would work for him. He was anxious to give it a try and was seeking my opinion. My answer... I have zero experience in using injectable or oral peptides for knee joint pain nor was unaware of any recognized medical organization backing these products. The internet is buzzing, however, with information about BPC-157 and TB-500 for joint health, injury and recovery. But can we separate fact from fiction? Lets take a "joint venture" in exploring, and dont miss our new section of the newsletter!

Arthrokinetix: Delving Deeper into TB-500 and BPC-157

In this edition of Arthrokinetix, we delve into the science (and hype) of TB-500 (Thymosin beta-4) and BPC-157 (Body Protective Compound-157). Often hailed by fitness enthusiasts as the "Wolverine Stack" for their purported regenerative properties, these peptides have ignited interest in the realm of orthopedic injury and recovery. Influencers such as Joe Rogan and Andrew Huberman have touted their benefits. (see below)

But first... what are peptides? Peptides are short chains of amino acids. As these chains of amino acids become longer they are called proteins. Peptides are in a shorter range of 2-50 amino acids. Peptides may perform certain functions in cells. Insulin, for example, is a peptide as is the currently popular medication Ozempic.

Origins and Scientific Intrigue:

• TB-500: TB-500 is a synthetic peptide of the naturally occurring healing protein present in about all human and mammalian cells known as Thymosin Beta 4 (TB4). It was first isolated from a calf thymus is 1981 and now is synthetically produced. While its exact mechanism of action remains under investigation, some studies suggest it may play a role in cell proliferation, angiogenesis (new blood vessel formation), and collagen synthesis – all crucial for tissue repair [1].

• BPC-157: BPC stands for body protective compound and 157 for the protein sequence. Derived from a protective complex found in gastric juice, BPC-157 exhibits a wide range of potential benefits. Studies have explored its effects on gut health, wound healing, and even protection against gastric ulcers [2]. Interestingly, research suggests BPC-157 might enhance the activity of growth hormone, potentially contributing to tissue repair throughout the body [3].

The Fitness Influencer Frenzy:

Fitness influencers often tout TB-500 and BPC-157 as wonder drugs for accelerating injury recovery. A simple TikTok or YouTube search will reveal a plethora of anecdotal support. Influencers such as Joe Rogan and Andrew Huberman have discussed their support. However, it's crucial to approach these claims with a critical eye. Actual clinical trials on humans are lacking, hence the reason for the FDA ban. (see below)

• Limited Evidence: While some pre-clinical studies on animals and small human trials show promise [4, 5], larger, well-designed clinical trials are needed to confirm efficacy and safety in humans. There are no randomized controlled studies in humans at this time. Here's one small retrospective study of 17 patients, 12 of whom received knee injections of BPC-157. Reportedly 11 of the 12 felt significant pain relief.

• Dosage and Delivery Uncertainties: Optimal dosages and administration methods (injection, oral) for these peptides remain unclear, complicating their use outside of a controlled research settings. Also, as supplements, the purity of the product is subject to third party testing and manufactures are not held to verification.

Banned by the FDA and WADA:

The FDA has banned BPC-157 from compounding pharmacies citing risk for immunogenicity, peptide-related impurities, and limited safety-related information. TB-500 and BPC-157 are both banned by the World Anti-Doping Agency (WADA) in the category of S0 unapproved substances.

Proposed Applications in Orthopedics:

Despite the lack of definitive evidence, some orthopedic researchers and fitness enthusiast's are exploring the potential of TB-500 and BPC-157 for:

• Tendon and Ligament Repair: Studies suggest TB-500 might promote collagen synthesis and reduce inflammation, potentially aiding tendon and ligament healing.

• Bone Regeneration: Early research indicates TB-500's potential role in bone growth and fracture healing.

• Post-Surgical Recovery: BPC-157's proposed wound healing and anti-inflammatory properties could theoretically enhance recovery following orthopedic surgery.

The Road Ahead:

The story of TB-500 and BPC-157 continues to unfold. With the allure of the reported benefits, interests in use will certainly continue. Peptides in general are trending with the popularity of medically supported medications like Ozempic. The initial data is intriguing, but more rigorous research is needed to determine their true potential and place in orthopedic practice. At Arthrokinetix, we'll plan to revisit these peptides for future application and will keep you informed of the latest scientific developments.

Remember: Consulting a qualified healthcare professional is best before considering TB-500 or BPC-157.

Introducing "Joint Ventures"

This new section of Arthrokinetix is dedicated to blending fun, creativity, and inspiration into our exploration of orthopedic topics. Here, you’ll find a mix of lighthearted pictures, comics, quotes, poems, and more. We will explore themes of health, healing, resilience, and the intersection of technology and human experience. All will somehow relate to orthopedics, kinetic movement and.... joints! As a special feature, some of these offerings will be available as mintable NFTs, allowing you to collect unique digital pieces from our community. So without further ado.... enjoy Joint Ventures, Harmony in Motion.

"The human body is the best picture of the human soul."
— Ludwig Wittgenstein

Stay tuned for the next edition of ArthroKinetix!

Please note: This information is for educational and infomational purposes only and should not be seen as medical advice.

References:

• [1] Kharraz et al. (2011) Thymosin beta-4: Stimulation of cell migration and wound healing through Akt and ERK 1/2 activation. Journal of Molecular Medicine: https://pubmed.ncbi.nlm.nih.gov/15565145/

• [2] Konturek et al. (2017) Pleiotropic effects of BPC157 in health and disease. Physiological Research: https://pubmed.ncbi.nlm.nih.gov/21030672/

• [3] Zaborowska et al. (2017) The effect of BPC 157 on growth hormone release in male rats. Experimental and Clinical Endocrinology & Diabetes: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271067/

• [4] Almeida et al. (2013) Thymosin beta-4 fragment improves healing of chronic cutaneous wounds in diabetic mice. Wound Repair and Regeneration: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930262/)

• [5] Amorim et al. (2014) Effects of Thymosin beta-4 on Achilles tendon healing in an experimental model. [Journal