The PredictionMany disease-causing DNA changes (variants) within gene regulatory elements might be found to play a role in multiple tissues or organs simultaneously (i.e., pleiotropic effect) to drive a convergent disease phenotype, contrary to the belief that regulatory elements are highly tissue-specific. Example: Multiple variants control the expression of IRX3 and IRX5 genes in both human adipose tissue and brain, the coordinated effects of which (less thermogenesis and more feeding behav...