In addition to homologs of previously described selenoproteins, we identified six new selenoprotein families, which were represented by at least two individual TGA-containing ORFs (total of 17 genes, Table 2). Most of these new families did not correspond to domains of known function and were not homologous to protein families with known functions. Multiple alignments of these new selenoproteins and their Cys-containing homologs (Figure 4) highlight sequence conservation of Sec/Cys pairs and ...