• Personalized cancer vaccines surge. mRNA‑4157 plus pembrolizumab cut melanoma recurrence by 44%, with benefits persisting at three years; a Memorial Sloan Kettering–BioNTech vaccine for pancreatic cancer generated durable immune responses and lower recurrence; layered lipid‑nanoparticle vaccines converted “cold” brain tumours “hot” within 48 h. Over 120 RNA cancer‑vaccine trials are now active and the first approvals could come as early as 2029

• Klotho gene therapy extends life. Elevating levels of the anti‑aging protein Klotho via a viral vector increased mice lifespans by 15–20 % and improved muscle, bone and cognitive function; researchers envision delivering the protein directly or using gene‑therapy vectors in humans

• Engineered “super” stem cells rejuvenate monkeys. Chinese scientists enhanced the FOXO3 longevity gene in human stem cells and injected them into aged macaques; the senescence‑resistant cells improved memory, restored brain connectivity, reduced inflammation and bone loss and rejuvenated over half of the 61 tissues examined, with no adverse events

• Partial epigenetic reprogramming inches toward clinic. Life Biosciences uses three Yamanaka factors (OSK) to reset aging cells. In animals, the ER‑300 program improved liver health in a steatohepatitis model, while ER‑100 restored methylation patterns and neuronal regeneration in a primate eye‑disease model; first‑in‑human trials are slated for 2026

• Senolytics show cognitive promise. In a small trial of older adults at risk for Alzheimer’s, intermittent doses of dasatinib and quercetin removed senescent cells; participants with the lowest baseline cognition improved by about 2 points on the Montreal Cognitive Assessment and their blood levels of the inflammatory marker TNF‑α fell

• Fasting‑mimicking diet rolls back biological age. Cycles of a five‑day, low‑protein plant‑based diet reduced insulin resistance, liver fat and other disease risk factors and cut biological age by roughly 2.5 years on average, showing that periodic diet interventions can rejuvenate metabolic and immune systems without permanent lifestyle changes .

• When you eat matters. A long‑term study of 2,945 older adults found that delaying breakfast and shrinking the daily eating window were linked to depression, fatigue, poor sleep and a higher risk of death. Early, consistent meal times could be an easy‑to‑track marker of overall health and a practical longevity lever

• BCI neuroprosthesis lets ALS patients “speak.” UC Davis researchers developed a brain‑computer interface that decodes attempted speech into text with up to 97 % accuracy, enabling a man with ALS to communicate within minutes of activation. It offers hope for restoring communication to people with paralysis or severe speech impairment

• The BCI pipeline is heating up. By mid‑2025 roughly 90 BCI trials worldwide were testing implants for communication, mobility and stroke rehabilitation; none are yet approved, but venture‑capital investment and public interest suggest BCIs could move from experimental devices to regulated treatments within a few years

• Rapamycin and canine longevity. The Dog Aging Project received a $7 M NIH grant to expand its trial of rapamycin to 580 dogs. Earlier studies showed small doses of this transplant drug improved heart function in dogs and mimic the benefits of intermittent fasting; researchers hope the trial will reveal whether rapamycin can extend canine lifespan and offer insights for human aging