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In the automotive circle, it is estimated that no one can play more than Tesla. Four days later, the recognized “price slaughter” priced twice and was seen as a friend of the network. One Tesla left the middle strand to tell the “markets” that company price regulation looks at the depth of the stock, that “the stock is not available, that it is not available, that there is a Maori space to lower prices without space and that sales are being promoted”. In four days, the Tesla price was raised ...
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In April, automobile production and sales "double drop" new energy vehicles performed well
On May 11, the latest production and sales data released by China Automobile Industry Association showed that in April, the production and sales of 1.205 million and 1.181 million vehicles decreased by 46.2% and 47.1% month on month and 46.1% and 47.6% year-on-year respectively. From January to April, the production and sales of automobiles were 7.69 million and 7.691 million respectively, with a year-on-year decrease of 10.5% and 12.1% respectively. The China Automobile Association pointed o...
Tetrane is to understand prices
In the automotive circle, it is estimated that no one can play more than Tesla. Four days later, the recognized “price slaughter” priced twice and was seen as a friend of the network. One Tesla left the middle strand to tell the “markets” that company price regulation looks at the depth of the stock, that “the stock is not available, that it is not available, that there is a Maori space to lower prices without space and that sales are being promoted”. In four days, the Tesla price was raised ...
Polygon tailor completed 100 million yen pre seed round financing
Polygon tailor Co., Ltd. and polygon tailor Consulting Co., Ltd. recently announced the completion of a pre seed round of financing of 100 million yen (about 5.5 million yuan). This financing is funded by a third-party allotment, with individual investors as underwriters and raised from four listed companies kushim, seamen, nex group and FISCO, The two companies are expected to use the funds to develop a virtual avatar sales and transformation platform, and enter the meta universe. Polygon ta...
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Studies have shown that changes in meal time seem to affect metabolic changes and elevated postprandial blood glucose. For diabetics, melatonin level is also an influential factor besides meal time.
Melatonin is a hormone secreted in large quantities at night or in weak light. Its main function is to regulate the sleep wake cycle. So how do melatonin receptor genes and dinner time affect an individual’s blood glucose control? Is there any association between the risk of type 2 diabetes and the risk of type 2 diabetes?
Recently, researchers from the Harvard Medical School Massachusetts General Hospital (MGH) and the Brigham and Women (s Hospital, BWH) scholar, the joint research team from the United States and Spain explored this issue and published research results in the diabetes Journal (Diabetes Care). The results showed that: 1) 1 hours before bedtime (when endogenous melatonin level was high), eating supper resulted in low insulin secretion and impaired glucose tolerance, which increased the risk of type 2 diabetes. 2) Especially in individuals with melatonin receptor MTNR1B gene mutation, this risk is higher.
Previous studies have shown that melatonin receptor 1B gene (MTNR1B) can increase the risk of type 2 diabetes and gestational diabetes mellitus, which has been considered as a genetic bridge between circadian rhythm and glucose metabolism.
The purpose of this study is to explore whether carriers of type 2 diabetes related G alleles, especially in the MTNR1B gene, are involved in the increase of endogenous melatonin levels (such as before bedtime). The randomized crossover study included 845 Spanish adults aged 18 and -70 who had no diabetes history and no history of drug use.
The study set up two meal times: “early dinner group”, that is, eating dinner 4 hours before the regular sleep time; And “late dinner group”, i.e. eating dinner 1 hour before normal sleep time. All subjects were randomly divided into one group, then changed to another group on the other night, and then repeated the test of relevant indicators.
Eating dinner was simulated by an oral glucose tolerance test. After fasting for 8 hours, each subject took 75 grams of glucose beverage orally for the next two nights to simulate early and late eating. The glucose tolerance (blood glucose and insulin response) of the two groups of subjects within 2 hours after meal (every 30 minutes) and the difference between MTNR1B G allele carriers and non carriers were recorded.
Too late for dinner, poor blood glucose control
The research team found that,
Melatonin levels in the blood of subjects in the late dinner group were 3.5 times higher than those in the early dinner group.
Late dinner time also led to the area under the insulin curve (AUC), which is used to evaluate islets β The index of cell function) decreased by 6.7%, and the AUC of glucose increased by 8.3%, that is, the later the dinner time, the lower the insulin level and the higher the blood glucose level. The researchers say the association is reasonable because insulin reduces blood glucose levels.
Subjects with the MTNR1B G allele had higher blood glucose levels than those without this gene variant when they ate late at dinner. Genotypic differences in glucose tolerance were attributed to the MTNR1B G allele population β Decreased cell function.
The results showed that carbohydrate intake (a typical feature of late eating), especially MTNR1B G allele carriers, while endogenous melatonin levels increased, impaired blood glucose control, which could be attributed to defective insulin secretion.
Therefore, late dinner time increases the risk of diabetes.
Evidence for prevention of type 2 diabetes mellitus
“Our findings may be important for strategies to prevent type 2 diabetes.” Dr. Frank a.j.l. Scheer, CO senior author of the study and director of the BWh medical chronobiology program, said.
“The findings apply to about a third of the population in the industrialized world, including people who eat near bedtime, others who eat at night (including night shift workers, or those with jet lag and eating disorders), and people who use large amounts of melatonin supplements,” he added
The researchers point out that it is wise for the general population to fast at least four hours before going to bed.
Future exploration and Prospect
“Genotypic information on melatonin receptor variants may help develop individualized behavioral recommendations,” said Dr. Richa Saxena, lead researcher and senior author at MGH genomics medical center
She also stressed, “it is worth noting that our research does not include diabetes patients, so more research is needed to examine the effect of eating time in diabetic patients and its relationship with melatonin and genetic variation.”
Related reading
BMJ study of tens of millions of people: beware of high body mass index and thick waist! Increased risk of type 2 diabetes
ADA’s latest diabetes guideline: it is recommended that all people start screening at the age of 35. Metformin may not be the first choice. China’s diabetes mellitus 20 years study: high risk of cancer, obesity and blood glucose fluctuation are incentives. What kinds of cancer should we pay attention to? The compliance rate is less than 20%! AHA’s latest appeal: diabetics should pay attention to these 7 kinds of “heart care” strategies.
The depth of the Lancet: diabetes, sugar control concept to change! Three major indicators, two new technologies and four types of new therapies deserve attention
reference material
[1] Marta Garaulet， Jesus Lopez-Minguez， et al。， （2022）。 Interplay of Dinner Timing and MTNR1BType 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion： ARandomized
Studies have shown that changes in meal time seem to affect metabolic changes and elevated postprandial blood glucose. For diabetics, melatonin level is also an influential factor besides meal time.
Melatonin is a hormone secreted in large quantities at night or in weak light. Its main function is to regulate the sleep wake cycle. So how do melatonin receptor genes and dinner time affect an individual’s blood glucose control? Is there any association between the risk of type 2 diabetes and the risk of type 2 diabetes?
Recently, researchers from the Harvard Medical School Massachusetts General Hospital (MGH) and the Brigham and Women (s Hospital, BWH) scholar, the joint research team from the United States and Spain explored this issue and published research results in the diabetes Journal (Diabetes Care). The results showed that: 1) 1 hours before bedtime (when endogenous melatonin level was high), eating supper resulted in low insulin secretion and impaired glucose tolerance, which increased the risk of type 2 diabetes. 2) Especially in individuals with melatonin receptor MTNR1B gene mutation, this risk is higher.
Previous studies have shown that melatonin receptor 1B gene (MTNR1B) can increase the risk of type 2 diabetes and gestational diabetes mellitus, which has been considered as a genetic bridge between circadian rhythm and glucose metabolism.
The purpose of this study is to explore whether carriers of type 2 diabetes related G alleles, especially in the MTNR1B gene, are involved in the increase of endogenous melatonin levels (such as before bedtime). The randomized crossover study included 845 Spanish adults aged 18 and -70 who had no diabetes history and no history of drug use.
The study set up two meal times: “early dinner group”, that is, eating dinner 4 hours before the regular sleep time; And “late dinner group”, i.e. eating dinner 1 hour before normal sleep time. All subjects were randomly divided into one group, then changed to another group on the other night, and then repeated the test of relevant indicators.
Eating dinner was simulated by an oral glucose tolerance test. After fasting for 8 hours, each subject took 75 grams of glucose beverage orally for the next two nights to simulate early and late eating. The glucose tolerance (blood glucose and insulin response) of the two groups of subjects within 2 hours after meal (every 30 minutes) and the difference between MTNR1B G allele carriers and non carriers were recorded.
Too late for dinner, poor blood glucose control
The research team found that,
Melatonin levels in the blood of subjects in the late dinner group were 3.5 times higher than those in the early dinner group.
Late dinner time also led to the area under the insulin curve (AUC), which is used to evaluate islets β The index of cell function) decreased by 6.7%, and the AUC of glucose increased by 8.3%, that is, the later the dinner time, the lower the insulin level and the higher the blood glucose level. The researchers say the association is reasonable because insulin reduces blood glucose levels.
Subjects with the MTNR1B G allele had higher blood glucose levels than those without this gene variant when they ate late at dinner. Genotypic differences in glucose tolerance were attributed to the MTNR1B G allele population β Decreased cell function.
The results showed that carbohydrate intake (a typical feature of late eating), especially MTNR1B G allele carriers, while endogenous melatonin levels increased, impaired blood glucose control, which could be attributed to defective insulin secretion.
Therefore, late dinner time increases the risk of diabetes.
Evidence for prevention of type 2 diabetes mellitus
“Our findings may be important for strategies to prevent type 2 diabetes.” Dr. Frank a.j.l. Scheer, CO senior author of the study and director of the BWh medical chronobiology program, said.
“The findings apply to about a third of the population in the industrialized world, including people who eat near bedtime, others who eat at night (including night shift workers, or those with jet lag and eating disorders), and people who use large amounts of melatonin supplements,” he added
The researchers point out that it is wise for the general population to fast at least four hours before going to bed.
Future exploration and Prospect
“Genotypic information on melatonin receptor variants may help develop individualized behavioral recommendations,” said Dr. Richa Saxena, lead researcher and senior author at MGH genomics medical center
She also stressed, “it is worth noting that our research does not include diabetes patients, so more research is needed to examine the effect of eating time in diabetic patients and its relationship with melatonin and genetic variation.”
Related reading
BMJ study of tens of millions of people: beware of high body mass index and thick waist! Increased risk of type 2 diabetes
ADA’s latest diabetes guideline: it is recommended that all people start screening at the age of 35. Metformin may not be the first choice. China’s diabetes mellitus 20 years study: high risk of cancer, obesity and blood glucose fluctuation are incentives. What kinds of cancer should we pay attention to? The compliance rate is less than 20%! AHA’s latest appeal: diabetics should pay attention to these 7 kinds of “heart care” strategies.
The depth of the Lancet: diabetes, sugar control concept to change! Three major indicators, two new technologies and four types of new therapies deserve attention
reference material
[1] Marta Garaulet， Jesus Lopez-Minguez， et al。， （2022）。 Interplay of Dinner Timing and MTNR1BType 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion： ARandomized
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