For over 5,000 years, peyote (Lophophora williamsii) has been a sacred medicine for Indigenous peoples across North America, serving as a portal to spiritual insight, healing, and cultural continuity. Its use is deeply embedded in the rituals of the Native American Church (NAC), a syncretic faith blending traditional Indigenous beliefs with Christian elements, where peyote is revered as a sacrament that facilitates direct communion with the Creator. The NAC, founded in the early 20th century,...